{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:43:21Z","timestamp":1793094201363,"version":"4.5.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,4,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The impact of atrial fibrillation (AF) in intermediate surgical risk patients with severe aortic stenosis who undergo either transcatheter or surgical aortic valve replacement (AVR) is not well established.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Data were assessed in 2663 patients from the PARTNER (Placement of Aortic Transcatheter Valve) 2A or S3i trials. Analyses grouped patients into 3 categories according to their baseline and discharge rhythms (ie, sinus rhythm [SR]\/SR, SR\/AF, or AF\/AF). Among patients with transcatheter AVR (n=1867), 79.2% had SR\/SR, 17.6% had AF\/AF, and 3.2% had SR\/AF. Among patients with surgical AVR (n=796), 71.7% had SR\/SR, 14.1% had AF\/AF, and 14.2% had SR\/AF. Patients with transcatheter AVR in AF at discharge had increased 2\u2010year mortality (SR\/AF versus SR\/SR; hazard ratio [HR], 2.73; 95% CI, 1.68\u20134.44;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001; AF\/AF versus SR\/SR; HR, 1.56; 95% CI, 1.16\u20132.09;\n              <jats:italic>P<\/jats:italic>\n              =0.003); patients with SR\/AF also experienced increased 2\u2010year mortality relative to patients with AF\/AF (HR, 1.77; 95% CI, 1.04\u20133.00;\n              <jats:italic>P<\/jats:italic>\n              =0.03). For patients with surgicalAVR, the presence of AF at discharge was also associated with increased 2\u2010year mortality (SR\/AF versus SR\/SR; HR, 1.93; 95% CI, 1.25\u20132.96;\n              <jats:italic>P<\/jats:italic>\n              =0.002; and AF\/AF versus SR\/SR; HR, 1.67; 95% CI, 1.06\u20132.63;\n              <jats:italic>P<\/jats:italic>\n              =0.027). Rehospitalization and persistent advanced heart failure symptoms were also more common among patients with transcatheter AVR and surgical AVR discharged in AF, and major bleeding was more common in the transcatheter AVR cohort.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The presence of AF at discharge in patients with intermediate surgical risk aortic stenosis was associated with worse outcomes\u2014especially in patients with baseline SR\u2014including increased all\u2010cause mortality at 2\u2010year follow\u2010up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifiers: NCT01314313 and NCT03222128.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.019584","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T09:41:10Z","timestamp":1616492470000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Atrial Fibrillation Is Associated With Mortality in Intermediate Surgical Risk Patients With Severe Aortic Stenosis: Analyses From the PARTNER 2A and PARTNER S3i Trials"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2606-055X","authenticated-orcid":false,"given":"Michael I.","family":"Brener","sequence":"first","affiliation":[{"name":"Division of Cardiology NewYork Presbyterian\u2010Columbia University Medical Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7770-4450","authenticated-orcid":false,"given":"Isaac","family":"George","sequence":"additional","affiliation":[{"name":"Division of Cardiology NewYork Presbyterian\u2010Columbia University Medical Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Kosmidou","sequence":"additional","affiliation":[{"name":"Division of Cardiology NewYork Presbyterian\u2010Columbia University Medical Center New York NY"},{"name":"Cardiovascular Research Foundation New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamim","family":"Nazif","sequence":"additional","affiliation":[{"name":"Division of Cardiology NewYork Presbyterian\u2010Columbia University Medical Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3838-4719","authenticated-orcid":false,"given":"Zixuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Dizon","sequence":"additional","affiliation":[{"name":"Division of Cardiology NewYork Presbyterian\u2010Columbia University Medical Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Garan","sequence":"additional","affiliation":[{"name":"Division of Cardiology NewYork Presbyterian\u2010Columbia University Medical Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0704-0334","authenticated-orcid":false,"given":"S. Chris","family":"Malaisrie","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Makkar","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Medical Center Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mack","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Health Plano TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson Y.","family":"Szeto","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1799-1368","authenticated-orcid":false,"given":"William F.","family":"Fearon","sequence":"additional","affiliation":[{"name":"Stanford University Stanford CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod H.","family":"Thourani","sequence":"additional","affiliation":[{"name":"Piedmont Heart &amp; Vascular Institute Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin B.","family":"Leon","sequence":"additional","affiliation":[{"name":"Division of Cardiology NewYork Presbyterian\u2010Columbia University Medical Center New York NY"},{"name":"Cardiovascular Research Foundation New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susheel","family":"Kodali","sequence":"additional","affiliation":[{"name":"Division of Cardiology NewYork Presbyterian\u2010Columbia University Medical Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0502-4418","authenticated-orcid":false,"given":"Angelo B.","family":"Biviano","sequence":"additional","affiliation":[{"name":"Division of Cardiology NewYork Presbyterian\u2010Columbia University Medical Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31829a33d1"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20969"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199710000-00011"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8090-7-87"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.4103\/2231-0770.102280"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.02.081"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103510"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514616"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.08.078"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.046"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.115.002766"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30073-3"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.01.037"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114705"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.05.042"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.06.019"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2015.04.023"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.110981"},{"key":"e_1_3_1_22_2","first-page":"544","article-title":"Antiplatelet and antithrombotic treatment after transcatheter aortic valve implantation\u2014comparison of regimes","volume":"25","author":"Poliacikova P","year":"2013","unstructured":"Poliacikova P, Cockburn J, de Belder A, Trivedi U, Hildick\u2010Smith D. 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Watch\u2010TAVR watchman for patients with atrial fibrillation undergoing transcatheter aortic valve replacement. 2021."}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.019584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:17:38Z","timestamp":1715599058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.019584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,6]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,4,6]]}},"alternative-id":["10.1161\/JAHA.120.019584"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.019584","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,6]]},"assertion":[{"value":"2020-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e019584"}}