{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:57:55Z","timestamp":1792699075176,"version":"4.5.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,5,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">We compared the cognitive status and quality of life in patients with atrial fibrillation undergoing left atrial appendage occlusion (LAAO) or remaining on oral anticoagulation (OAC) after atrial fibrillation ablation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Cognition was assessed by the Montreal Cognitive Assessment (MoCA) survey at baseline and follow\u2010up. Consecutive patients receiving LAAO or OAC after atrial fibrillation ablation were screened, and patients with a score of \u226417 were excluded from the study. Quality of life was measured at baseline and 1 year using the Atrial Fibrillation Effect on Quality of Life survey. A total of 50 patients (CHA\n              <jats:sub>2<\/jats:sub>\n              DS\n              <jats:sub>2<\/jats:sub>\n              \u2010VASc [congestive heart failure, hypertension, age\u226575\u00a0years, diabetes mellitus, stroke or transient ischemic attack, vascular disease, age 65\u201374\u00a0years, sex category] score: 3.30\u00b11.43) in the LAAO group and 48 (CHA\n              <jats:sub>2<\/jats:sub>\n              DS\n              <jats:sub>2<\/jats:sub>\n              \u2010VASc score 2.73\u00b11.25) in the OAC group were included in this prospective study. Mean baseline MoCA score was 26.18 and 26.08 in the LAAO and OAC groups, respectively (\n              <jats:italic>P<\/jats:italic>\n              =0.846). At 1 year, scores were 26.94 and 23.38 in the respective groups. MoCA score decreased by an estimated \u22122.74 (95% CI, \u22123.61 to \u22121.87;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) points in the OAC group, whereas the change in the LAAO group was nonsignificant (0.79; (95% CI, \u22120.06 to 1.64;\n              <jats:italic>P<\/jats:italic>\n              =0.07). After adjusting for baseline clinical characteristics, remaining on OAC was an independent predictor of MoCA change at 1 year (regression coefficient, \u22123.38; 95% CI, \u22124.75 to \u22122.02;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001). Change in Atrial Fibrillation Effect on Quality of Life score did not differ significantly in achieving a clinically important difference between groups.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In this series, a significant difference in the postprocedure MoCA score was observed in postablation patients with atrial fibrillation receiving LAAO versus remaining on OAC with a substantial decline in the score in the OAC group. However, quality of life improved similarly across groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.ClinicalTrials.gov\">https:\/\/www.ClinicalTrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT01816308\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.019664","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T20:01:29Z","timestamp":1624305689000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Impact of Oral Anticoagulation Therapy Versus Left Atrial Appendage Occlusion on Cognitive Function and Quality of Life in Patients With Atrial Fibrillation"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6601-944X","authenticated-orcid":false,"given":"Sanghamitra","family":"Mohanty","sequence":"first","affiliation":[{"name":"Texas Cardiac Arrhythmia InstituteSt. David's Medical Center Austin TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasant","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia InstituteSt. David's Medical Center Austin TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chintan","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia InstituteSt. David's Medical Center Austin TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3086-7062","authenticated-orcid":false,"given":"Joanna","family":"Assadourian","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia InstituteSt. David's Medical Center Austin TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1973-8254","authenticated-orcid":false,"given":"Angel Quintero","family":"Mayedo","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia InstituteSt. David's Medical Center Austin TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3819-8273","authenticated-orcid":false,"given":"Bryan","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia InstituteSt. David's Medical Center Austin TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3837-3462","authenticated-orcid":false,"given":"Domenico G.","family":"Della Rocca","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia InstituteSt. David's Medical Center Austin TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8174-7207","authenticated-orcid":false,"given":"Carola","family":"Gianni","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia InstituteSt. David's Medical Center Austin TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney","family":"Horton","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia InstituteSt. David's Medical Center Austin TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8547-025X","authenticated-orcid":false,"given":"Amin","family":"Al\u2010Ahmad","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia InstituteSt. David's Medical Center Austin TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Bassiouny","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia InstituteSt. David's Medical Center Austin TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia InstituteSt. David's Medical Center Austin TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6508-4047","authenticated-orcid":false,"given":"Luigi","family":"Di Biase","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia InstituteSt. David's Medical Center Austin TX"},{"name":"Albert Einstein College of Medicine at Montefiore Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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