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Influenza vaccination has been shown to be protective against cardiovascular and cerebrovascular events in several observational and prospective studies of at\u2010risk populations. Hence, many international guidelines recommend influenza vaccination for adults of all ages, especially for individuals with high\u2010risk conditions such as CVD. Despite these long\u2010standing recommendations, influenza vaccine uptake among US adults with CVD remains suboptimal. Specifically, vaccination uptake is strikingly low among patients aged &lt;65\u00a0years, non\u2010Hispanic Black individuals, those without health insurance, and those with diminished access to healthcare services. Behavioral factors such as perceived vaccine efficacy, vaccine safety, and attitudes towards vaccination play an important role in vaccine acceptance at the individual and community levels. With the ongoing COVID\u201019 pandemic, there is a potential threat of a concurrent epidemic with influenza. This would be devastating for vulnerable populations such as adults with CVD, further stressing the need for ensuring adequate influenza vaccination coverage. In this review, we describe a variety of strategies to improve the uptake of influenza vaccination in patients with CVD through improved understanding of key sociodemographic determinants and behaviors that are associated with vaccination, or the lack thereof. We further discuss the potential use of relevant strategies for COVID\u201019 vaccine uptake among those with CVD.<\/jats:p>","DOI":"10.1161\/jaha.120.019671","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T08:57:24Z","timestamp":1627462644000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":52,"title":["Determinants of Influenza Vaccine Uptake in Patients With Cardiovascular Disease and Strategies for Improvement"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1959-5759","authenticated-orcid":false,"given":"Priyanka","family":"Bhugra","sequence":"first","affiliation":[{"name":"Hospital MedicineHouston Methodist Hospital Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2800-2150","authenticated-orcid":false,"given":"Gowtham R.","family":"Grandhi","sequence":"additional","affiliation":[{"name":"Department of Medicine MedStar Union Memorial Hospital Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8152-8031","authenticated-orcid":false,"given":"Reed","family":"Mszar","sequence":"additional","affiliation":[{"name":"Center for Outcomes Research and EvaluationYale New Haven Health New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Satish","sequence":"additional","affiliation":[{"name":"Department of CardiologyHouston Methodist Hospital Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Houston Methodist Hospital Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5138-9683","authenticated-orcid":false,"given":"Michael","family":"Blaha","sequence":"additional","affiliation":[{"name":"Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Blankstein","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Program, Cardiovascular Division and Department of Radiology Brigham and Women's Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9541-6954","authenticated-orcid":false,"given":"Salim S.","family":"Virani","sequence":"additional","affiliation":[{"name":"Michael E. 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