{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:54:29Z","timestamp":1792446869336,"version":"4.5.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,4,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">We aimed to investigate whether there are differences in cardiac structure and systolic and diastolic function evaluated by 2\u2010dimensional echocardiography among men living with versus without HIV in the era of combination antiretroviral therapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We performed a cross\u2010sectional analysis of 1195 men from MACS (Multicenter AIDS Cohort Study) who completed a transthoracic echocardiogram examination between 2017 and 2019. Associations between HIV serostatus and echocardiographic indices were assessed by multivariable regression analyses, adjusting for demographics and cardiovascular risk factors. Among men who are HIV+, associations between HIV disease severity markers and echocardiographic parameters were also investigated. Average age was 57.1\u00b111.9\u00a0years; 29% of the participants were Black, and 55% were HIV+. Most men who were HIV+ (77%) were virally suppressed; 92% received combination antiretroviral therapy. Prevalent left ventricular (LV) systolic dysfunction (ejection fraction &lt;50%) was low and HIV serostatus was not associated with left ventricular ejection fraction. Multivariable adjustment models showed that men who were HIV+ versus those who were HIV\u2212 had greater LV mass index and larger left atrial diameter and right ventricular (RV) end\u2010diastolic area; lower RV function; and higher prevalence of diastolic dysfunction. Higher current CD4+ T cell count \u2265400\u00a0cell\/mm\n              <jats:sup>3<\/jats:sup>\n              versus &lt;400 was associated with smaller LV diastolic volume and RV area. Virally suppressed men who were HIV+ versus those who were HIV\u2212 had higher indexed LV mass and left atrial areas and greater diastolic dysfunction.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">HIV seropositivity was independently associated with greater LV mass index, left atrial and RV sizes, lower RV function and diastolic abnormalities, but not left ventricular ejection fraction, which may herald a future predisposition to heart failure with preserved ejection fraction among men living with HIV.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.019709","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T10:21:21Z","timestamp":1616235681000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Associations Between HIV Serostatus and Cardiac Structure and Function Evaluated by 2\u2010Dimensional Echocardiography in the Multicenter AIDS Cohort Study"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9758-2240","authenticated-orcid":false,"given":"Henrique","family":"Doria de Vasconcellos","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy S.","family":"Post","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore MD"},{"name":"Johns Hopkins Bloomberg School of Public Health Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Margret","family":"Ervin","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9467-3454","authenticated-orcid":false,"given":"Sabina Annette","family":"Haberlen","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9616-1946","authenticated-orcid":false,"given":"Matthew","family":"Budoff","sequence":"additional","affiliation":[{"name":"Lundquist Institute at Harbor\u2010UCLA Medical Center Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3156-2965","authenticated-orcid":false,"given":"Carlos","family":"Malvestutto","sequence":"additional","affiliation":[{"name":"Department of Medicine Ohio State University OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5075-3604","authenticated-orcid":false,"given":"Jared W.","family":"Magnani","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8958-7666","authenticated-orcid":false,"given":"Matthew J.","family":"Feinstein","sequence":"additional","affiliation":[{"name":"Department of Medicine Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd T.","family":"Brown","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8756-6995","authenticated-orcid":false,"given":"Joao A. C.","family":"Lima","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4958-5145","authenticated-orcid":false,"given":"Katherine C.","family":"Wu","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-018-0400-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000065"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001384"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000695"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-019-00458-1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.0264"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.05.027"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2019.08.001"},{"key":"e_1_3_2_10_2","first-page":"176","article-title":"Echocardiographic findings and abnormalities in HIV\u2010infected patients: results from a large, prospective, multicenter HIV\u2010heart study","volume":"1","author":"Reinsch N","year":"2011","unstructured":"Reinsch N, Kahlert P, Esser S, Sundermeyer A, Neuhaus K, Brockmeyer N, Potthoff A, Erbel R, Buck T, Neumann T. Echocardiographic findings and abnormalities in HIV\u2010infected patients: results from a large, prospective, multicenter HIV\u2010heart study. Am J Cardiovasc Dis. 2011;1:176\u2013184.","journal-title":"Am J Cardiovasc Dis"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2018.08.010"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.12.036"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2013.04.007"},{"key":"e_1_3_2_14_2","unstructured":"Centers for Disease Control and Prevention . \u201cHIV in the United States and dependent areas.\u201d 2018. Available at: https:\/\/www.cdc.gov\/hiv\/statistics\/overview\/ataglance.html. Accessed August 14 2020."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/126.2.310"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2018.06.004"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.55.4.613"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2018.02.001"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.10.006"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.12.004"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2020.01.002"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.04.083"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(18)30043-2"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.01.011"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2018.08.011"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kww214"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jex252"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871526516666161205124309"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.004574"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2018.06.003"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2008.0170"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.854943"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq066"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201708-1555OC"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-014-0610-8"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.4.1133"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.019709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:19:42Z","timestamp":1715599182000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.019709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,6]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,4,6]]}},"alternative-id":["10.1161\/JAHA.120.019709"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.019709","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,6]]},"assertion":[{"value":"2020-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e019709"}}