{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:26:09Z","timestamp":1790313969219,"version":"4.1.0"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,9,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The relationship between long\u2010term cardiovascular health (CVH) patterns and elevated CRP (C\u2010reactive protein) in late middle age has yet to be investigated. We aimed to assess this relationship.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Individual CVH components were measured in 4405 Black and White men and women (aged 18\u201330 years at baseline) in the CARDIA (Coronary Artery Risk Development in Young Adults) study at 8 examinations over 25\u00a0years. CRP was measured at 4 examinations (years 7, 15, 20, and 25). Latent class modeling was used to identify individuals with similar trajectories in CVH from young adulthood to middle age. Multivariable Poisson regression models were used to assess the association between race\u2010specific CVH trajectories and prevalence of elevated CRP levels (&gt;3.0\u00a0mg\/L) after 25\u00a0years of follow\u2010up. Five distinct CVH trajectories were identified for each race. Lower and decreasing trajectories had higher prevalence of elevated CRP relative to the highest trajectory. Prevalence ratios for elevated CRP in lowest trajectory groups at year 25 were 2.58 (95% CI, 1.89\u20133.51) and 7.20 (95% CI, 5.09\u201310.18) among Black and White people, respectively. Prevalence ratios for chronically elevated CRP (elevated CRP at 3 or more of the examinations) in the lowest trajectory groups were 8.37 (95% CI, 4.37\u201316.00) and 15.89 (95% CI, 9.01\u201328.02) among Black and White people, respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Lower and decreasing CVH trajectories are associated with higher prevalence of elevated CRP during the transition from young adulthood to middle age.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.019725","type":"journal-article","created":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T09:05:02Z","timestamp":1629536702000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Cardiovascular Health Trajectories and Elevated C\u2010Reactive Protein: The CARDIA Study"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5398-2173","authenticated-orcid":false,"given":"Jonathan J.","family":"Ruiz\u2010Ramie","sequence":"first","affiliation":[{"name":"Department of Kinesiology Augusta University Augusta GA"},{"name":"Department of Exercise Science Arnold School of Public Health University of South Carolina Columbia SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8132-1601","authenticated-orcid":false,"given":"Jacob L.","family":"Barber","sequence":"additional","affiliation":[{"name":"Department of Exercise Science Arnold School of Public Health University of South Carolina Columbia SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0847-6110","authenticated-orcid":false,"given":"Donald M.","family":"Lloyd\u2010Jones","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Feinberg School of Medicine Northwestern University Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myron D.","family":"Gross","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota Minneapolis MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal S.","family":"Rana","sequence":"additional","affiliation":[{"name":"Division of Cardiology Kaiser Permanente of Northern California Oakland CA"},{"name":"Division of Research Kaiser Permanente of Northern California Oakland CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Sidney","sequence":"additional","affiliation":[{"name":"Division of Research Kaiser Permanente of Northern California Oakland CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7232-0543","authenticated-orcid":false,"suffix":"Jr","given":"David 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