{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:40:06Z","timestamp":1783456806881,"version":"3.55.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,4,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Hypertension among young adults is common. However, the effect of isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), or systolic and diastolic hypertension (SDH) among young adults on chronic kidney disease (CKD) development is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">From a nationwide health screening database, we included 3\u00a0030\u00a0884 participants aged 20 to 39\u00a0years who were not taking antihypertensives at baseline examination in 2009 to 2010. Participants were categorized as having normal blood pressure (BP), elevated BP, stage 1 IDH, stage 1 ISH, stage 1 SDH, stage 2 IDH, stage 2 ISH, and stage 2 SDH. The primary outcome was incident CKD. A total of 5853 (0.19%) CKD events occurred. With normal BP as the reference, multivariable\u2010adjusted hazard ratios (HRs) (95% CIs) for CKD were 1.14 (95% CI, 1.04\u20131.26), elevated BP; 1.19 (95% CI, 1.10\u20131.28), stage 1 IDH; 1.24 (95% CI, 1.08\u20131.42), stage 1 ISH; 1.39 (95% CI, 1.28\u20131.51), stage 1 SDH; 1.88 (95% CI, 1.63\u20132.16), stage 2 IDH; 1.84 (95% CI, 1.54\u20132.19), stage 2 ISH; 2.70 (95% CI, 2.44\u20132.98), stage 2 SDH. The HRs for CKD were attenuated in the patients who were antihypertensive and began medication within 1\u00a0year of medical checkup than in those without antihypertensives.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Among Korean young adults, those with elevated BP, stage 1 IDH, stage 1 ISH, stage 1 SDH, stage 2 IDH, stage 2 ISH, and stage 2 SDH were associated with a higher CKD risk than those with normal BP. The CKD risk in ISH and IDH groups was similar but lower than that in the SDH group. Antihypertensives attenuated the risk of CKD in young adults with hypertension.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.019764","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T09:52:43Z","timestamp":1617184363000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Chronic Kidney Disease Risk of Isolated Systolic or Diastolic Hypertension in Young Adults: A Nationwide Sample Based\u2010Cohort Study"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1727-2822","authenticated-orcid":false,"given":"Eun Hui","family":"Bae","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Yeob","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Korea University Ansan Hospital Ansan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Hyung","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Ryom","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Sang","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8753-7641","authenticated-orcid":false,"given":"Chang Seong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Kwon","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung\u2010Do","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Statistics and Actuarial Science Soongsil University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3540-9004","authenticated-orcid":false,"given":"Soo Wan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.13820"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht151"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000207"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000065"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.668921"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30228-5"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.11498"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02146-2"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.12.1501"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.036312"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032582"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.3961\/jpmph.2013.46.6.353"},{"key":"e_1_3_1_14_2","first-page":"e15","article-title":"Cohort profile: the National Health Insurance Service\u2010National Sample Cohort (NHIS\u2010NSC), South Korea","volume":"46","author":"Lee J","year":"2017","unstructured":"Lee J, Lee JS, Park SH, Shin SA, Kim K. 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