{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:27:25Z","timestamp":1791397645444,"version":"4.3.3"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,5,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Abnormal cardiac repolarization is observed in patients with epilepsy and can be associated with sudden death. We investigated whether structural brain abnormalities are correlated with abnormal cardiac repolarizations in patients with seizure or epilepsy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We retrospectively analyzed and compared 12\u2010lead ECG parameters following seizures between patients with and without structural brain abnormalities. A total of 96 patients were included: 33 women (17 with and 16 without brain abnormality) and 63 men (44 with and 19 without brain abnormality). Brain abnormalities included past stroke, chronic hematoma, remote bleeding, tumor, trauma, and postsurgical state. ECG parameters were comparable for heart rate, PR interval, and QRS duration between groups. In contrast, corrected QT intervals evaluated by Fridericia, Framingham, and Bazett formulas were prolonged in patients with brain abnormality compared with those without (women: Fridericia [normal versus abnormal], 397.4\u00b132.7 versus 470.9\u00b148.9;\n              <jats:italic>P<\/jats:italic>\n              =0.002; Framingham, 351.0\u00b140.1 versus 406.2\u00b146.1;\n              <jats:italic>P<\/jats:italic>\n              =0.002; Bazett, 423.8\u00b138.3 versus 507.7\u00b156.6;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001; men: Fridericia, 403.8\u00b130.4 versus 471.0\u00b147.1;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001; Framingham, 342.7\u00b136.4 versus 409.4\u00b145.8;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001; Bazett, 439.3\u00b138.6 versus 506.2\u00b156.8;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001). QT dispersion and T\n              <jats:sub>peak<\/jats:sub>\n              \u2212T\n              <jats:sub>end<\/jats:sub>\n              intervals were comparable between groups. We also observed abnormal ST\u2010segment elevation in 5 patients. Importantly, no patients showed fatal arrhythmias during or after seizures.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Our study demonstrated that brain abnormalities can be associated with abnormal cardiac repolarization after seizures, which might be a manifestation of electrophysiological remodeling in the brain.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.019778","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T10:41:38Z","timestamp":1619433698000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Abnormal Cardiac Repolarization After Seizure Episodes in Structural Brain Diseases: Cardiac Manifestation of Electrical Remodeling in the Brain?"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7238-6705","authenticated-orcid":false,"given":"Shusuke","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Acute Critical Care and Disaster Medicine Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3216-3499","authenticated-orcid":false,"given":"Isik","family":"Turker","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine Vanderbilt University Medical Center Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoki","family":"Inaji","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Epilepsy Center Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Bello\u2010Pardo","sequence":"additional","affiliation":[{"name":"Division of Human Genetics Department of Internal Medicine Ohio State University College of Medicine Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Miida","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Otomo","sequence":"additional","affiliation":[{"name":"Department of Acute Critical Care and Disaster Medicine Tokyo Medical and Dental University Tokyo 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