{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:45:22Z","timestamp":1782992722780,"version":"3.54.5"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,3,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Cardiac resynchronization therapy with defibrillation (CRT\u2010D) improves outcomes in heart failure. The long\u2010term impact of CRT\u2010D on hospitalizations remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We analyzed the MADIT\u2010CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy) trial post hoc to assess the effects of CRT\u2010D versus implantable cardioverter\u2010defibrillator (ICD) on cardiovascular, heart failure (HF), and noncardiovascular hospitalizations. Hospitalization rates, length of stay, and mortality were compared during extended follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Patients receiving CRT\u2010D had lower rates of hospitalization compared with ICD (37.9 events per 100 patient\u2010years versus 44.3 events per 100 patient\u2010years,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.033). Rates of cardiovascular hospitalizations (20.8 versus 28.3 events per 100 patient\u2010years;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) and heart failure hospitalizations (6.8 versus 11.6 events per 100 patient\u2010years;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) were lower with CRT\u2010D. There was no difference in noncardiovascular hospitalizations in the CRT\u2010D group compared with ICD (17 versus 16 events per 100 patient\u2010years,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.368). The average length of stay for cardiovascular hospitalizations was shorter in the CRT\u2010D group versus the ICD group (6.7\u00b10.89 versus 7.7\u00b10.68\u2009days;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), as was the length of stay for heart failure hospitalizations (4.2\u00b10.79 versus 4.8\u00b10.58\u2009days;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). No difference was observed in the length of stay for noncardiovascular hospitalizations (8.1 versus 7.0\u2009days;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.082). Hospitalization of any type was associated with a markedly increased risk of death (hazard ratio, 8.97 [95% CI, 6.17\u201313.05];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among patients in MADIT\u2010CRT, CRT\u2010D was associated with lower rates and shorter durations of all cardiovascular hospitalizations, including heart failure hospitalizations compared with ICD alone. Hospitalization, regardless of cause, was strongly associated with increased mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT00180271\">https:\/\/clinicaltrials.gov\/study\/NCT00180271<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.120.019880","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T10:19:24Z","timestamp":1772187564000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Cardiac Resynchronization Therapy on Cardiovascular and Noncardiovascular Hospitalization: A\u00a0MADIT\u2010CRT Long\u2010Term Follow\u2010Up"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5336-9504","authenticated-orcid":false,"given":"Sabu","family":"Thomas","sequence":"first","affiliation":[{"name":"University of Rochester School of Medicine","place":["Rochester, USA"]},{"name":"University of Rochester School of Medicine","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5374-6322","authenticated-orcid":false,"given":"Scott","family":"McNitt","sequence":"additional","affiliation":[{"name":"University of Rochester School of Medicine","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0114-1174","authenticated-orcid":false,"given":"Bronislava","family":"Polonsky","sequence":"additional","affiliation":[{"name":"University of Rochester School of Medicine","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Alexis","sequence":"additional","affiliation":[{"name":"University of Rochester School of Medicine","place":["Rochester, USA"]},{"name":"University of Rochester School of Medicine","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Bisognano","sequence":"additional","affiliation":[{"name":"University of Michigan School of Medicine","place":["Ann Arbor, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5806-3325","authenticated-orcid":false,"given":"Ilan","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"University of Rochester School of Medicine","place":["Rochester, USA"]},{"name":"University of Rochester School of Medicine","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-289X","authenticated-orcid":false,"given":"Valentina","family":"Kutyifa","sequence":"additional","affiliation":[{"name":"University of Rochester School of Medicine","place":["Rochester, USA"]},{"name":"University of Rochester School of Medicine","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2015.05.002"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032423"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009540"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.5388"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.333"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa0803563"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000417"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.960898"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906431"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013474"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.7205\/MILMED-D-17-00017"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.07.016"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.007787"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2015.1614"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.019880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:11:39Z","timestamp":1782990699000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.019880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,3,17]]}},"alternative-id":["10.1161\/JAHA.120.019880"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.019880","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]},"assertion":[{"value":"2020-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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