{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:33:27Z","timestamp":1790166807795,"version":"4.1.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,7,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Heart failure (HF) imposes significant burden on patients and caregivers. Longitudinal data on caregiver health\u2010related quality of life (HRQOL) and burden in ambulatory advanced HF are limited.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Ambulatory patients with advanced HF (n=400) and their participating caregivers (n=95) enrolled in REVIVAL (Registry Evaluation of Vital Information for VADs [Ventricular Assist Devices] in Ambulatory Life) were followed up for 24\u00a0months, or until patient death, left ventricular assist device implantation, heart transplantation, or loss to follow\u2010up. Caregiver HRQOL (EuroQol Visual Analog Scale) and burden (Oberst Caregiving Burden Scale) did not change significantly from baseline to follow\u2010up. At time of caregiver enrollment, better patient HRQOL by Kansas City Cardiomyopathy Questionnaire was associated with better caregiver HRQOL (\n              <jats:italic>P<\/jats:italic>\n              =0.007) and less burden by both time spent (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) and difficulty (\n              <jats:italic>P<\/jats:italic>\n              =0.0007) of caregiving tasks. On longitudinal analyses adjusted for baseline values, better patient HRQOL (\n              <jats:italic>P<\/jats:italic>\n              =0.034) and being a married caregiver (\n              <jats:italic>P<\/jats:italic>\n              =0.016) were independently associated with better caregiver HRQOL. Patients with participating caregivers (versus without) were more likely to prefer left ventricular assist device therapy over time (odds ratio, 1.43; 95% CI, 1.03\u20131.99;\n              <jats:italic>P<\/jats:italic>\n              =0.034). Among patients with participating caregivers, those with nonmarried (versus married) caregivers were at higher composite risk of HF hospitalization, death, heart transplantation or left ventricular assist device implantation (hazard ratio, 2.99; 95% CI, 1.29\u20136.96;\n              <jats:italic>P<\/jats:italic>\n              =0.011).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Patient and caregiver characteristics may impact their HRQOL and other health outcomes over time. Understanding the patient\u2010caregiver relationship may better inform medical decision making and outcomes in ambulatory advanced HF.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.019901","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T09:17:00Z","timestamp":1625908620000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Caregiver Health\u2010Related Quality of Life, Burden, and Patient Outcomes in Ambulatory Advanced Heart Failure: A Report From REVIVAL"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4511-8008","authenticated-orcid":false,"given":"Nisha A.","family":"Gilotra","sequence":"first","affiliation":[{"name":"Johns Hopkins Hospital Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salpy V.","family":"Pamboukian","sequence":"additional","affiliation":[{"name":"University of Alabama 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C.","family":"Forde\u2010McLean","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald C.","family":"Haas","sequence":"additional","affiliation":[{"name":"Abington\u2010Jefferson Health Abington PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Horstmanshof","sequence":"additional","affiliation":[{"name":"IACC Advanced Cardiac Care Department INTEGRIS Baptist Medical Center Oklahoma City OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9476-6466","authenticated-orcid":false,"given":"Ulrich P.","family":"Jorde","sequence":"additional","affiliation":[{"name":"Montefiore Medical Center Bronx NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart D.","family":"Russell","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine Durham 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