{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:46:35Z","timestamp":1784040395878,"version":"3.55.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,9,7]]},"abstract":"<jats:sec xml:lang=\"en\"><jats:title>Background<\/jats:title><jats:p xml:lang=\"en\">Little research has evaluated patient bleeding risk perceptions in comparison with calculated bleeding risk among oral anticoagulant users with atrial fibrillation. Our objective was to investigate underestimation of bleeding risk and to describe the characteristics and patient\u2010reported outcomes associated with underestimation of bleeding risk.<\/jats:p><\/jats:sec><jats:sec xml:lang=\"en\"><jats:title>Methods and Results<\/jats:title><jats:p xml:lang=\"en\">In the SAGE\u2010AF (Systematic Assessment of Geriatric Elements in Atrial Fibrillation) study, a prospective cohort study of patients \u226565\u00a0years with atrial fibrillation, a CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc risk score \u22652 and who were on oral anticoagulant therapy, we compared patients\u2019 self\u2010reported bleeding risk with their predicted bleeding risk from their HAS\u2010BLED score. Among the 754 participants (mean age 74.8\u00a0years, 48.3% women), 68.0% underestimated their bleeding risk. Participants who were Asian or Pacific Islander, Black, Native American or Alaskan Native, Mixed Race or Hispanic (non\u2010White) (adjusted OR [AOR], 0.45; 95% CI, 0.24\u20130.82) and women (AOR, 0.62; 95% CI, 0.40\u20130.95) had significantly lower odds of underestimating their bleeding risk than respective comparison groups. Participants with a history of bleeding (AOR, 3.07; 95% CI, 1.73\u20135.44) and prior hypertension (AOR, 4.33; 95% CI, 2.43\u20137.72), stroke (AOR, 5.18; 95% CI, 1.87\u201314.40), or renal disease (AOR, 5.05; 95% CI, 2.98\u20138.57) had significantly higher odds of underestimating their bleeding risk.<\/jats:p><\/jats:sec><jats:sec xml:lang=\"en\"><jats:title>Conclusions<\/jats:title><jats:p xml:lang=\"en\">We found that more than two\u2010thirds of patients with atrial fibrillation on oral anticoagulant therapy underestimated their bleeding risk and that participants with a history of bleeding and several comorbid conditions were more likely to underestimate their bleeding risk whereas non\u2010Whites and women were less likely to underestimate their bleeding risk. Clinicians should ensure that patients prescribed oral anticoagulant therapy have a thorough understanding of bleeding risk.<\/jats:p><\/jats:sec>","DOI":"10.1161\/jaha.120.019979","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T17:57:27Z","timestamp":1629136647000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Differences in Perceived and Predicted Bleeding Risk in Older Adults With Atrial Fibrillation: The SAGE\u2010AF Study"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1645-5838","authenticated-orcid":false,"given":"Benita A.","family":"Bamgbade","sequence":"first","affiliation":[{"name":"Department of Pharmacy and Health System Sciences Northeastern University Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David D.","family":"McManus","sequence":"additional","affiliation":[{"name":"Cardiology Division 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