{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:02:40Z","timestamp":1791910960809,"version":"4.3.4"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,5,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Survivors of myocardial infarction are at increased risk of late ventricular arrhythmias, with infarct size and scar heterogeneity being key determinants of arrhythmic risk. Gap junctions facilitate the passage of small ions and morphogenic cell signaling between myocytes. We hypothesized that gap junctions enhancement during infarction\u2013reperfusion modulates structural and electrophysiological remodeling and reduces late arrhythmogenesis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Infarction\u2013reperfusion surgery was carried out in male Sprague\u2010Dawley rats followed by 7\u00a0days of rotigaptide or saline administration. The in vivo and ex vivo arrhythmogenicity was characterized by programmed electrical stimulation 3\u00a0weeks later, followed by diffusion\u2010weighted magnetic resonance imaging and Masson's trichrome histology. Three weeks after 7\u2010day postinfarction administration of rotigaptide, ventricular tachycardia\/ventricular fibrillation was induced on programmed electrical stimulation in 20% and 53% of rats, respectively (rotigaptide versus control), resulting in reduction of arrhythmia score (3.2 versus 1.4,\n              <jats:italic>P<\/jats:italic>\n              =0.018), associated with the reduced magnetic resonance imaging parameters fractional anisotropy (fractional anisotropy: \u22125% versus \u221215%;\n              <jats:italic>P<\/jats:italic>\n              =0.062) and mean diffusivity (mean diffusivity: 2% versus 6%,\n              <jats:italic>P<\/jats:italic>\n              =0.042), and remodeling of the 3\u2010dimensional laminar structure of the infarct border zone with reduction of the mean (16\u00b0 versus 19\u00b0,\n              <jats:italic>P<\/jats:italic>\n              =0.013) and the dispersion (9\u00b0 versus 12\u00b0,\n              <jats:italic>P<\/jats:italic>\n              =0.015) of the myofiber transverse angle. There was no change in ECG features, spontaneous arrhythmias, or mortality.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Enhancement of gap junctions function by rotigaptide administered during the early healing phase in reperfused infarction reduces later complexity of infarct scar morphology and programmed electrical stimulation\u2013induced arrhythmias, and merits further exploration as a feasible and practicable intervention in the acute myocardial infarction management to reduce late arrhythmic risk.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.020006","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T10:15:53Z","timestamp":1618654553000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Rotigaptide Infusion for the First 7\u00a0Days After Myocardial Infarction\u2013Reperfusion Reduced Late Complexity of Myocardial Architecture of the Healing Border\u2010Zone and Arrhythmia Inducibility"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4204-1014","authenticated-orcid":false,"given":"Rasheda A.","family":"Chowdhury","sequence":"first","affiliation":[{"name":"National Heart &amp; Lung Institute and ElectroCardioMaths Programme of the Imperial Centre for Cardiac EngineeringImperial College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Debney","sequence":"additional","affiliation":[{"name":"National Heart &amp; Lung Institute and ElectroCardioMaths Programme of the Imperial Centre for Cardiac EngineeringImperial College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Protti","sequence":"additional","affiliation":[{"name":"King\u2019s British Heart Foundation Centre School of Cardiovascular Medicine and Sciences Kings College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7028-2942","authenticated-orcid":false,"given":"Balvinder S.","family":"Handa","sequence":"additional","affiliation":[{"name":"National Heart &amp; Lung Institute and ElectroCardioMaths Programme of the Imperial Centre for Cardiac EngineeringImperial College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran H. 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