{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:42:22Z","timestamp":1788367342477,"version":"build-2803163510"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,7,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">It remains unclear whether beta\u2010blocker use at hospital admission is associated with better in\u2010hospital outcomes in patients with acute decompensated heart failure.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We evaluated the factors independently associated with beta\u2010blocker use at admission, and the effect of beta\u2010blocker use at admission on in\u2010hospital mortality in 3817 patients with acute decompensated heart failure enrolled in the Kyoto Congestive Heart Failure registry. There were 1512 patients (39.7%) receiving, and 2305 patients (60.3%) not receiving beta\u2010blockers at admission for the index acute decompensated heart failure hospitalization. Factors independently associated with beta\u2010blocker use at admission were previous heart failure hospitalization, history of myocardial infarction, atrial fibrillation, cardiomyopathy, and estimated glomerular filtration rate &lt;30\u00a0mL\/min per 1.73\u00a0m\n              <jats:sup>2<\/jats:sup>\n              . Factors independently associated with no beta\u2010blocker use were asthma, chronic obstructive pulmonary disease, lower body mass index, dementia, older age, and left ventricular ejection fraction &lt;40%. Patients on beta\u2010blockers had significantly lower in\u2010hospital mortality rates (4.4% versus 7.6%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Even after adjusting for confounders, beta\u2010blocker use at admission remained significantly associated with lower in\u2010hospital mortality risk (odds ratio, 0.41; 95% CI, 0.27\u20130.60,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Furthermore, beta\u2010blocker use at admission was significantly associated with both lower cardiovascular mortality risk and lower noncardiovascular mortality risk. The association of beta\u2010blocker use with lower in\u2010hospital mortality risk was relatively more prominent in patients receiving high dose beta\u2010blockers. The magnitude of the effect of beta\u2010blocker use was greater in patients with previous heart failure hospitalization than in patients without (\n              <jats:italic>P<\/jats:italic>\n              for interaction 0.04).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Beta\u2010blocker use at admission was associated with lower in\u2010hospital mortality in patients with acute decompensated heart failure.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.upload.umin.ac.jp\/\">https:\/\/www.upload.umin.ac.jp\/<\/jats:ext-link>\n              ; Unique identifier: UMIN000015238.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.020012","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T09:00:20Z","timestamp":1624698020000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Lower In\u2010Hospital Mortality With Beta\u2010Blocker Use at Admission in Patients With Acute Decompensated Heart Failure"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0217-6598","authenticated-orcid":false,"given":"Yodo","family":"Tamaki","sequence":"first","affiliation":[{"name":"Department of Cardiology Tenri Hospital Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Yaku","sequence":"additional","affiliation":[{"name":"Department of Cardiology Mitsubishi Kyoto Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6844-739X","authenticated-orcid":false,"given":"Takeshi","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Hyogo College of Medicine Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutaka","family":"Inuzuka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Shiga General Hospital Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neiko","family":"Ozasa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8082-2036","authenticated-orcid":false,"given":"Yusuke","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9519-6637","authenticated-orcid":false,"given":"Makoto","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tenri Hospital Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tenri Hospital Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tenri Hospital Nara 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