{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:11:59Z","timestamp":1765807919393,"version":"3.41.2"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The prothrombotic defect factor V Leiden (FVL) may confer higher risk of ST\u2010segment\u2013elevation myocardial infarction (STEMI), compared with non\u2013ST\u2010segment\u2013elevation acute coronary syndrome, and may be associated with more myocardial necrosis caused by higher thrombotic burden.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Patients without history of cardiovascular disease were selected from 2 clinical trials conducted in patients with acute coronary syndrome. FVL was defined as G\u2010to\u2010A substitution at nucleotide 1691 in the factor V (factor V R506Q) gene. Odds ratios were calculated for the association of FVL with STEMI adjusted for age and sex in the overall population and in the subgroups including sex, age (\u226570 versus &lt;70\u00a0years), and traditional cardiovascular risk factors. The peak biomarker levels (ie, creatine kinase\u2010myocardial band and high\u2010sensitivity troponin I or T) after STEMI were contrasted between FVL carriers and noncarriers. Because of differences in troponin assays, peak high\u2010sensitivity troponin levels were converted to a ratio scale. The prevalence of FVL mutation was comparable in patients with STEMI (6.0%) and non\u2013ST\u2010segment\u2013elevation acute coronary syndrome (5.8%). The corresponding sex\u2010 and age\u2010adjusted odds ratio was 1.06 (95% CI, 0.86\u20131.30;\n              <jats:italic>P<\/jats:italic>\n              =0.59) for the association of FVL with STEMI. Subgroup analysis did not show any differences. In patients with STEMI, neither the median peak creatine kinase\u2010myocardial band nor the peak high\u2010sensitivity troponin ratio showed any differences between wild\u2010type and FVL carriers (\n              <jats:italic>P<\/jats:italic>\n              for difference: creatine kinase\u2010myocardial band=0.33; high sensitivity troponin ratio=0.54).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In a general population with acute coronary syndrome, FVL did not discriminate between a STEMI or non\u2013ST\u2010segment\u2013elevation acute coronary syndrome presentation and was unrelated to peak cardiac necrosis markers in patients with STEMI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifiers: NCT00391872 and NCT01761786.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.020025","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T09:43:17Z","timestamp":1621244597000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Factor V Leiden Does Not Modify the Phenotype of Acute Coronary Syndrome or the Extent of Myocardial Necrosis"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6455-473X","authenticated-orcid":false,"given":"Bakhtawar K.","family":"Mahmoodi","sequence":"first","affiliation":[{"name":"Department of Cardiology St. Antonius Hospital Nieuwegein the Netherlands"},{"name":"Division of Hemostasis and Thrombosis Department of Hematology UMC GroningenUniversity of Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2152-4343","authenticated-orcid":false,"given":"Niclas","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Uppsala Clinical Research Center Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerrit J. A.","family":"Vos","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Antonius Hospital Nieuwegein the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"Meijer","sequence":"additional","affiliation":[{"name":"Division of Hemostasis and Thrombosis Department of Hematology UMC GroningenUniversity of Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agneta","family":"Siegbahn","sequence":"additional","affiliation":[{"name":"Uppsala Clinical Research Center Uppsala University Uppsala Sweden"},{"name":"Laboratory for Coagulation Research Clinical Chemistry Department of Medical Sciences University Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"James","sequence":"additional","affiliation":[{"name":"Uppsala Clinical Research Center Uppsala University Uppsala Sweden"},{"name":"Department of Medical Sciences Cardiology Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Wallentin","sequence":"additional","affiliation":[{"name":"Uppsala Clinical Research Center Uppsala University Uppsala Sweden"},{"name":"Department of Medical Sciences Cardiology Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurri\u00ebn M.","family":"ten Berg","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Antonius Hospital Nieuwegein the Netherlands"},{"name":"The Cardiovascular Research Institute Maastricht (CARIM) Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs411"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/157340312803217247"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-013-9825-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000160361.73423.23"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009136"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68263-9"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.045526"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2003.29"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.011201"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904327"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1907096"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.21980"},{"key":"e_1_3_2_14_2","volume-title":"R: A Language and Environment for Statistical Computing [Computer Program]","author":"R Development Core Team","year":"2017","unstructured":"R Development Core Team . R: A Language and Environment for Statistical Computing [Computer Program]. Vienna, Austria: R Foundation for Statistical Computing; 2017."}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.020025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:23:15Z","timestamp":1715599395000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.020025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1161\/JAHA.120.020025"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.020025","relation":{},"ISSN":["2047-9980"],"issn-type":[{"type":"electronic","value":"2047-9980"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"2020-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e020025"}}