{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T15:19:48Z","timestamp":1793891988499,"version":"4.8.0"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,5,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Aging leads to increased visceral adipose tissue (VAT) and reduced skeletal muscle density. To which extent these are associated with the risk of stroke, myocardial infarction (MI), and all\u2010cause mortality in older adults is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A total of 3294 70\u2010year\u2010old individuals (49.6% women) underwent a health examination in Ume\u00e5, Sweden, during 2012 to 2018. VAT and muscle density were measured using dual\u2010energy x\u2010ray absorptiometry and peripheral quantitative computed tomography. Cases of stroke, MI, and all\u2010cause mortality were collected through national registers. Cox regressions were used to calculate hazard ratios (HRs) and 95% CIs per SD greater VAT and per SD lower muscle density. During a mean follow\u2010up of 3.6\u00a0years, there were 108 cases of stroke or MI, and 97 deaths. Greater VAT (adjusted HR [aHR], 1.56; 95% CI, 1.09\u20132.22), but not lower muscle density (aHR, 1.14; 95% CI, 0.97\u20131.34), was associated with increased risk of stroke or MI. Neither VAT (aHR, 0.95; 95% CI, 0.65\u20131.41) nor muscle density (aHR, 1.11; 95% CI, 0.92\u20131.34) was associated with all\u2010cause mortality. The association of VAT with stroke or MI was only significant in men (aHR, 1.86; 95% CI, 1.19\u20132.91) but not women (aHR, 0.60; 95% CI, 0.25\u20131.42) (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>interaction<\/jats:sub>\n                      =0.038).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">With the limitation of being an observational study, these findings suggest that VAT is an important obesity\u2010related predictor of cardiovascular risk in 70\u2010year\u2010old men, and by implication, that decreasing VAT may potentially reduce their risk of cardiovascular disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.120.020065","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T06:12:09Z","timestamp":1618639929000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":45,"title":["Associations of Visceral Adipose Tissue and Skeletal Muscle Density With Incident Stroke, Myocardial Infarction, and All\u2010Cause Mortality in Community\u2010Dwelling 70\u2010Year\u2010Old Individuals: A Prospective Cohort Study"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9638-7208","authenticated-orcid":false,"given":"Marcel","family":"Ballin","sequence":"first","affiliation":[{"name":"Unit of Geriatric Medicine Department of Community Medicine and Rehabilitation Ume\u00e5 University Ume\u00e5 Sweden"},{"name":"Section of Sustainable Health Department of Public Health and Clinical Medicine Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2924-508X","authenticated-orcid":false,"given":"Peter","family":"Nordstr\u00f6m","sequence":"additional","affiliation":[{"name":"Unit of Geriatric Medicine Department of Community Medicine and Rehabilitation Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5050-3720","authenticated-orcid":false,"given":"Johan","family":"Niklasson","sequence":"additional","affiliation":[{"name":"Unit of Geriatric Medicine Department of Community Medicine and Rehabilitation Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3534-456X","authenticated-orcid":false,"given":"Anna","family":"Nordstr\u00f6m","sequence":"additional","affiliation":[{"name":"Section of Sustainable Health Department of Public Health and Clinical Medicine Ume\u00e5 University Ume\u00e5 Sweden"},{"name":"School of Sport Sciences UiT The Arctic University of Norway Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000757"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003138"},{"key":"e_1_3_2_4_2","volume-title":"Global Health Risks: Mortality and Burden of Disease Attributable to Selected Major Risks","author":"World Health Organization","year":"2009","unstructured":"World Health Organization . 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