{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T13:12:21Z","timestamp":1768482741665,"version":"3.49.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,8,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">We have previously reported the feasibility of noninvasive stereotactic body radiotherapy (SBRT) as a novel approach for renal denervation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Herein, from a translational point of view, we assessed the antihypertensive effect and chronological evolution of SBRT\u2010induced renal nerve injury within 6\u00a0months in a hypertensive swine model. Hypertension was induced in swine by subcutaneous implantation of deoxycorticosterone acetate pellets in combination with a high\u2010salt diet. A single dose of 25\u00a0Gy with SBRT was delivered for renal denervation in 9 swine within 3.4\u00b11.0\u00a0minutes. Blood pressure levels at baseline and 1 and 6\u00a0months post\u2010SBRT were comparable to control (n=5), whereas renal norepinephrine was significantly lower at 6\u00a0months (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05). Abdominal computed tomography, performed before euthanasia and renal function assessment, remained normal. Standard semiquantitative histological assessment showed that compared with control (1.4\u00b10.4), renal nerve injury was greater at 1\u00a0month post\u2010SBRT (2.3\u00b10.3) and peaked at 6\u00a0months post\u2010SBRT (3.2\u00b10.8) (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05), along with a higher proportion of active caspase\u20103\u2013positive nerves (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05). Moreover, SBRT resulted in continuous dysfunction of renal sympathetic nerves and low level of nerve regeneration in 6\u00a0months by immunohistochemistry analysis.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">SBRT delivering 25\u00a0Gy for renal denervation was safe and related to sustained reduction of sympathetic activity by aggravating nerve damage and inhibiting nerve regeneration up to 6\u00a0months; however, its translation to clinical trial should be cautious because of the negative blood pressure response in the deoxycorticosterone acetate\u2013salt hypertensive swine model.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.020068","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T09:28:04Z","timestamp":1628328484000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Renal Denervation by Noninvasive Stereotactic Radiotherapy Induces Persistent Reduction of Sympathetic Activity in a Hypertensive Swine Model"],"prefix":"10.1161","volume":"10","author":[{"given":"Xingxing","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Cardiology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichen","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Oncology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine 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