{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:28:36Z","timestamp":1789752516251,"version":"4.0.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,7,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">We studied care gap in patients with familial hypercholesterolemia (FH) with respect to lipid\u2010lowering therapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We enrolled patients with cardiovascular disease (CVD) or FH and low\u2010density lipoprotein\u2010cholesterol &gt;2.0\u00a0mmol\/L despite maximally tolerated statin therapy. During follow\u2010up physicians received online reminders of treatment recommendations of 2009 patients (median age, 63\u00a0years, 42% women), 52.4% had CVD only, 31.7% FH only, and 15.9% both CVD and FH. Patients with FH were younger and more likely to be women and non\u2010White with significantly higher baseline low\u2010density lipoprotein\u2010cholesterol level (mmol\/L) as compared with patients with CVD (FH 3.92\u00b11.48 versus CVD 2.96\u00b10.94,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001). Patients with FH received less statin (70.6% versus 79.2%,\n              <jats:italic>P<\/jats:italic>\n              =0.0001) at baseline but not ezetimibe (28.1% versus 20.4%,\n              <jats:italic>P<\/jats:italic>\n              =0.0003). Among patients with FH only, 45.3% were at low\u2010density lipoprotein target (\u2265 50% reduction from pre\u2010treatment level or low\u2010density lipoprotein &lt;2.5\u00a0mmol\/L) at baseline and increasing to 65.8% and 73.6% by visit 2 and 3, respectively. Among patients with CVD only, none were at recommended level (\u22642.0\u00a0mmol\/L) at baseline and 44.3% and 53.3% were at recommended level on second and third visit, respectively. When primary end point was analyzed as a difference between baseline and last available follow\u2010up observation, only 22.0% of patients with FH only achieved it as compared with 45.8% with CVD only (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) and 55.2% with both FH+CVD (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">There is significant treatment inertia in patients with FH including those with CVD. Education focused on patients with FH should continue to be undertaken.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.020126","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T08:54:21Z","timestamp":1625820861000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Treatment Inertia in Patients With Familial Hypercholesterolemia"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3974-5160","authenticated-orcid":false,"given":"Anatoly","family":"Langer","sequence":"first","affiliation":[{"name":"Canadian Heart Research Centre Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. B. John","family":"Mancini","sequence":"additional","affiliation":[{"name":"University of British Columbia Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Tan","sequence":"additional","affiliation":[{"name":"Canadian Heart Research Centre Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8068-2440","authenticated-orcid":false,"given":"Shaun G.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Canadian Heart Research Centre Toronto ON Canada"},{"name":"St Michael\u2019s HospitalUniversity of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5740-0484","authenticated-orcid":false,"given":"Vineeta","family":"Ahooja","sequence":"additional","affiliation":[{"name":"Canadian Heart Research Centre Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Gr\u00e9goire","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9alInstitut de cardiologie de Montr\u00e9al Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Lin","sequence":"additional","affiliation":[{"name":"Canadian Heart Research Centre Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Stone","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine University of Calgary Calgary Canada"},{"name":"Libin Cardiovascular Institute of Alberta Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence A.","family":"Leiter","sequence":"additional","affiliation":[{"name":"Li Ka Shing Knowledge InstituteSt. Michael\u2019s HospitalUniversity of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67394-1"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90815-X"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487317717346"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2016.07.510"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2018.09.005"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.533018"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(07)70882-6"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.11.015"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.04.009"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e3282f56513"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjco.2019.12.002"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.03.019"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2013.02.055"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(10)70454-2"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2017.279422"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.13861"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1410489"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1615664"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801174"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8071080"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.09.015"},{"key":"e_1_3_1_23_2","first-page":"102","article-title":"Can clinical reminder help optimize the use of secondary prevention therapies in non\u2010ST elevation acute coronary syndrome?","volume":"1","author":"Langer A","year":"2018","unstructured":"Langer A, Tan M, Cieza T, Ciomyk R, Graham J, Ramanathan K, Hamel R, Bernie V, Goodman SG. 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