{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:57:57Z","timestamp":1790470677332,"version":"4.1.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,5,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Dispersion and gradients in repolarization have been associated with life\u2010threatening arrhythmias, but are difficult to quantify precisely from surface electrocardiography. The objective of this study was to evaluate electrocardiographic imaging (ECGI) to noninvasively detect repolarization\u2010based abnormalities.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Ex vivo data were obtained from Langendorff\u2010perfused pig hearts (n=8) and a human donor heart. Unipolar electrograms were recorded simultaneously during sinus rhythm from an epicardial sock and the torso\u2010shaped tank within which the heart was suspended. Regional repolarization heterogeneities were introduced through perfusion of dofetilide and pinacidil into separate perfusion beds. In vivo data included torso and epicardial potentials recorded simultaneously in anesthetized, closed\u2010chest pigs (n=5), during sinus rhythm, and ventricular pacing. For both data sets, ECGI accurately reconstructed T\u2010wave electrogram morphologies when compared with those recorded by the sock (ex vivo: correlation coefficient, 0.85 [0.52\u20130.96], in vivo: correlation coefficient, 0.86 [0.52\u20130.96]) and repolarization time maps (ex\u2010vivo: correlation coefficient, 0.73 [0.63\u20130.83], in vivo: correlation coefficient, 0.76 [0.67\u20130.82]). ECGI\u2010reconstructed repolarization time distributions were strongly correlated to those measured by the sock (both data sets,\n              <jats:italic>R<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              \u22650.92). Although the position of the gradient was slightly shifted by 8.3 (0\u201313.9) mm, the mean, max, and SD between ECGI and recorded gradient values were highly correlated (\n              <jats:italic>R<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =0.87, 0.75, and 0.86 respectively). There was no significant difference in ECGI accuracy between ex vivo and in vivo data.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">ECGI reliably and accurately maps potentially critical repolarization abnormalities. This noninvasive approach allows imaging and quantifying individual parameters of abnormal repolarization\u2010based substrates in patients with arrhythmogenesis, to improve diagnosis and risk stratification.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.020153","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T20:01:29Z","timestamp":1624305689000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Electrocardiographic Imaging of Repolarization Abnormalities"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7070-2492","authenticated-orcid":false,"given":"Laura R.","family":"Bear","sequence":"first","affiliation":[{"name":"IHU\u2010LIRYCFondation Bordeaux Universit\u00e9 Pessac France"},{"name":"CRCTB U1045 Universit\u00e9 de Bordeaux Bordeaux France"},{"name":"Inserm U1045 CRCTB Pessac 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