{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:18:56Z","timestamp":1789823936444,"version":"4.0.1"},"reference-count":63,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,6,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Dietary Mg intake is associated with a decreased risk of developing heart failure, whereas low circulating Mg level is associated with increased cardiovascular mortality. We investigated whether Mg deficiency alone could cause cardiomyopathy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              C57BL\/6J mice were fed with a low Mg (low\u2010Mg, 15\u201330\u00a0mg\/kg Mg) or a normal Mg (nl\u2010Mg, 600\u00a0mg\/kg Mg) diet for 6\u00a0weeks. To test reversibility, half of the low\u2010Mg mice were fed then with nl\u2010Mg diet for another 6\u00a0weeks. Low\u2010Mg diet significantly decreased mouse serum Mg (0.38\u00b10.03 versus 1.14\u00b10.03\u00a0mmol\/L for nl\u2010Mg;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) with a reciprocal increase in serum Ca, K, and Na. Low\u2010Mg mice exhibited impaired cardiac relaxation (ratio between mitral peak early filling velocity E and longitudinal tissue velocity of the mitral anterior annulus e, 21.1\u00b11.1 versus 15.4\u00b10.4 for nl\u2010Mg;\n              <jats:italic>P<\/jats:italic>\n              =0.011). Cellular ATP was decreased significantly in low\u2010Mg hearts. The changes were accompanied by mitochondrial dysfunction with mitochondrial reactive oxygen species overproduction and membrane depolarization. cMyBPC (cardiac myosin\u2010binding protein C) was\n              <jats:italic>S<\/jats:italic>\n              \u2010glutathionylated in low\u2010Mg mouse hearts. All these changes were normalized with Mg repletion. In vivo (2\u2010(2,2,6,6\u2010tetramethylpiperidin\u20101\u2010oxyl\u20104\u2010ylamino)\u20102\u2010oxoethyl)triphenylphosphonium chloride treatment during low\u2010Mg diet improved cardiac relaxation, increased ATP levels, and reduced\n              <jats:italic>S<\/jats:italic>\n              \u2010glutathionylated cMyBPC.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Mg deficiency caused a reversible diastolic cardiomyopathy associated with mitochondrial dysfunction and oxidative modification of cMyBPC. In deficiency states, Mg supplementation may represent a novel treatment for diastolic heart failure.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.020205","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T09:17:24Z","timestamp":1622884644000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Magnesium Deficiency Causes a Reversible, Metabolic, Diastolic Cardiomyopathy"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1390-7862","authenticated-orcid":false,"given":"Man","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Medicine The Lillehei Heart InstituteUniversity of Minnesota at Twin Cities Minneapolis MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine The Lillehei Heart InstituteUniversity of Minnesota at Twin Cities Minneapolis MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Feng","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine The Lillehei Heart InstituteUniversity of Minnesota at Twin Cities Minneapolis MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Xie","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine The Lillehei Heart InstituteUniversity of Minnesota at Twin Cities Minneapolis MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyeoung\u2010Jin","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine The Lillehei Heart InstituteUniversity of Minnesota at Twin Cities Minneapolis MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine The Lillehei Heart InstituteUniversity of Minnesota at Twin Cities Minneapolis MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8692-6768","authenticated-orcid":false,"given":"Cody R.","family":"Hou","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine The Lillehei Heart InstituteUniversity of Minnesota at Twin Cities Minneapolis MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine The Lillehei Heart InstituteUniversity of Minnesota at Twin Cities Minneapolis MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5843-5961","authenticated-orcid":false,"suffix":"Jr","given":"Samuel C.","family":"Dudley","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine The Lillehei Heart InstituteUniversity of Minnesota at Twin Cities Minneapolis MN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000659"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052256"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.188965"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1245"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.123182"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.003046"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2012.12.003"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3945\/an.112.003483"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2010.11.011"},{"key":"e_1_3_2_11_2","first-page":"340","article-title":"The impact of changes in levels of calcium, phosphate and magnesium during hemodialysis on autonomic system reactivity as measured by heart rate variability analysis","volume":"57","author":"Buda S","year":"2000","unstructured":"Buda S, Stompor T, Sulowicz W, Kopec J, Szymczakiewicz\u2010Multanowska A, Janion M. 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