{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:19:02Z","timestamp":1784805542606,"version":"3.55.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,8,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The Essential Frailty Toolset (EFT) was shown to be easy to use and predictive of adverse events in patients undergoing aortic valve replacement procedures. The objective of this study was to evaluate the EFT in patients undergoing coronary artery bypass grafting procedures.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The McGill Frailty Registry prospectively included patients \u226560\u00a0years of age undergoing urgent or elective isolated coronary artery bypass grafting between 2011 and 2018 at 2 hospitals. The preoperative EFT was scored 0 to 5 points as a function of timed chair rises, Mini\u2010Mental Status Examination, serum albumin, and hemoglobin. The primary outcome was all\u2010cause mortality assessed by Cox proportional hazards regression. The cohort consisted of 500 patients with a mean age of 71.4\u00a0\u00b1\u00a06.4\u00a0years, of which 27% presented with acute coronary syndromes requiring urgent surgery. The mean EFT was 1.3\u00a0\u00b1\u00a01.1 points, 132 (26%) were nonfrail, 298 (60%) were prefrail, and 70 (14%) were frail. Over a median follow\u2010up of 4.0\u00a0years, 78 deaths were observed. In nonfrail, prefrail, and frail patients, survival at 1 year was 98%, 95%, and 91%, and at 5\u00a0years was 89%, 83%, and 63% (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). After adjustment, each incremental EFT point was associated with a hazard ratio of 1.28 (95% CI, 1.05\u20131.56) and frail patients had a 3\u2010fold increase in all\u2010cause mortality.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The EFT is a pragmatic and highly prognostic tool to assess frailty and guide decisions for coronary artery bypass grafting in older adults. Furthermore, the EFT may be actionable through targeted interventions such as cardiac rehabilitation and nutritional optimization.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.020219","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T09:00:09Z","timestamp":1627462809000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["The Essential Frailty Toolset in Older Adults Undergoing Coronary Artery Bypass Surgery"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3687-8029","authenticated-orcid":false,"given":"Joshua","family":"Solomon","sequence":"first","affiliation":[{"name":"Centre for Clinical Epidemiology Lady Davis Institute for Medical ResearchJewish General Hospital Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Moss","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Jewish General HospitalMcGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Francois","family":"Morin","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Jewish General HospitalMcGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Langlois","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Jewish General HospitalMcGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzo","family":"Cecere","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery McGill University Health Centre Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"de Varennes","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery McGill University Health Centre Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Lachapelle","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery McGill University Health Centre Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolo","family":"Piazza","sequence":"additional","affiliation":[{"name":"Division of Cardiology McGill University Health Centre Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Martucci","sequence":"additional","affiliation":[{"name":"Division of Cardiology McGill University Health Centre Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Bendayan","sequence":"additional","affiliation":[{"name":"Centre for Clinical Epidemiology Lady Davis Institute for Medical ResearchJewish General Hospital Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palina","family":"Piankova","sequence":"additional","affiliation":[{"name":"Centre for Clinical Epidemiology Lady Davis Institute for Medical ResearchJewish General Hospital Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0324-716X","authenticated-orcid":false,"given":"Victoria","family":"Hayman","sequence":"additional","affiliation":[{"name":"Centre for Clinical Epidemiology Lady Davis Institute for Medical ResearchJewish General Hospital Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Claude","family":"Ouimet","sequence":"additional","affiliation":[{"name":"Research InstituteMcGill University Health Centre Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence G.","family":"Rudski","sequence":"additional","affiliation":[{"name":"Division of Cardiology Jewish General HospitalMcGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0555-4937","authenticated-orcid":false,"given":"Jonathan","family":"Afilalo","sequence":"additional","affiliation":[{"name":"Centre for Clinical Epidemiology Lady Davis Institute for Medical ResearchJewish General Hospital Montreal QC Canada"},{"name":"Research InstituteMcGill University Health Centre Montreal QC Canada"},{"name":"Division of Cardiology Jewish General HospitalMcGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls119"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-016-0329-8"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.039"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.07.087"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2019.01.014"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.06.037"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.0316"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.M146"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.06.024"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2018.12.052"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-009-0214-7"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.10.114"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/36.4.428"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1985.tb06317.x"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.10.057"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03480170070031"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi720"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2019.02.040"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(02)00052-0"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_3_1_22_2","first-page":"138","article-title":"The utility of the frailty index in clinical decision making","volume":"7","author":"Khatry K","year":"2018","unstructured":"Khatry K, Peel NM, Gray LC, Hubbard RE. The utility of the frailty index in clinical decision making. J Frailty Aging. 2018;7:138\u2013141. DOI: 10.14283\/jfa.2018.7.","journal-title":"J Frailty Aging"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-017-0706-z"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23021"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2019.09.025"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezy222"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009882"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezz378"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.09.005"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12170-011-0186-0"},{"key":"e_1_3_1_31_2","first-page":"106","article-title":"Proceedings of the canadian frailty network workshop: Identifying biomarkers of frailty to support frailty risk assessment, Toronto, january 15, 2018","volume":"8","author":"Muscedere J","year":"2019","unstructured":"Muscedere J, Kim PM, Afilalo J, Balion C, Baracos VE, Bowdish D, Cesari M, Erusalimsky JD, F\u00fcl\u00f6p T, Heckman G, et al. Proceedings of the canadian frailty network workshop: Identifying biomarkers of frailty to support frailty risk assessment, Toronto, january 15, 2018. J Frailty Aging. 2019;8:106\u2010116. DOI: 10.14283\/jfa.2019.12.","journal-title":"J Frailty Aging"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2019.1153"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2019.07.002"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2016.03.003"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487317752373"},{"key":"e_1_3_1_36_2","first-page":"53","article-title":"The european innovation partnership on active and healthy ageing synergies: Protocol for a prospective observational study to measure the impact of a community\u2010based program on prevention and mitigation of frailty (icp \u2010 pmf) in community\u2010dwelling older adults","volume":"15","author":"Liotta G","year":"2016","unstructured":"Liotta G, Orfila F, Vollenbroek\u2010Hutten M, Roller\u2010Winsberger R, Illario M, Musian D, Alvino S, O'Caoimh R, Cano A, Molloy W, et al. The european innovation partnership on active and healthy ageing synergies: Protocol for a prospective observational study to measure the impact of a community\u2010based program on prevention and mitigation of frailty (icp \u2010 pmf) in community\u2010dwelling older adults. Transl Med UniSa. 2016;15:53\u201366.","journal-title":"Transl Med UniSa"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.11124\/JBISRIR-2017-003382"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.05.015"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.03.019"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53269.x"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.020219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:47:11Z","timestamp":1715600831000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.020219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,3]]},"references-count":39,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2021,8,3]]}},"alternative-id":["10.1161\/JAHA.120.020219"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.020219","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,3]]},"assertion":[{"value":"2020-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e020219"}}