{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:17:10Z","timestamp":1783034230133,"version":"3.54.6"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,1,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Coronary artery disease was hitherto a rarity in Africa. Acute coronary syndrome (ACS) accounts for coronary artery disease\u2013related morbidity and mortality. Reports on ACS in Africa are few.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We enrolled 1072 indigenous Nigerian people 59.2\u00b112.4\u00a0years old (men, 66.8%) with ACS in an observational multicentered national registry (2013\u20132018). Outcome measures included incidence, intervention times, reperfusion rates, and 1\u2010year mortality. The incidence of ACS was 59.1 people per 100\u00a0000 hospitalized adults per year, and comprised ST\u2010segment\u2013elevation myocardial infarction (48.7%), non\u2013ST\u2010segment\u2013elevation myocardial infarction (24.5%), and unstable angina (26.8%). ACS frequency peaked 10\u00a0years earlier in men than women. Patients were predominantly from urban settings (87.3%). Median time from onset of symptoms to first medical contact (patients with ST\u2010segment\u2013elevation myocardial infarction) was 6\u00a0hours (interquartile range, 20.1\u00a0hours), and only 11.9% presented within a 12\u2010hour time window. Traditional risk factors of coronary artery disease were observed. The coronary angiography rate was 42.4%. Reperfusion therapies included thrombolysis (17.1%), percutaneous coronary intervention (28.6%), and coronary artery bypass graft (11.2%). Guideline\u2010based pharmacotherapy was adequate. Major adverse cardiac events were 30.8%, and in\u2010hospital mortality was 8.1%. Mortality rates at 30\u00a0days, 3\u00a0months, 6\u00a0months, and 1\u00a0year were 8.7%, 9.9%, 10.9%, and 13.3%, respectively. Predictors of mortality included resuscitated cardiac arrest (odds ratio [OR], 50.0; 95% CI, 0.010\u20130.081), nonreperfusion (OR, 34.5; 95% CI, 0.004\u20130.221), pulmonary edema (OR, 11.1; 95% CI, 0.020\u20130.363), left ventricular diastolic dysfunction (OR, 4.1; 95% CI, 0.091\u20130.570), and left ventricular systolic dysfunction (OR, 2.1; 95% CI, 1.302\u20133.367).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">ACS burden is rising in Nigeria, and patients are relatively young and from an urban setting. The system of care is evolving and is characterized by lack of capacity and low patient eligibility for reperfusion. We recommend preventive strategies and health care infrastructure\u2010appropriate management guidelines.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.020244","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T11:41:52Z","timestamp":1640173312000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Registry for Acute Coronary Events in Nigeria (RACE\u2010Nigeria): Clinical Characterization, Management, and Outcome"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6849-7952","authenticated-orcid":false,"given":"Simeon","family":"Isezuo","sequence":"first","affiliation":[{"name":"Department of Medicine Usmanu Danfodiyo University &amp; Teaching Hospital Sokoto Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud Umar","family":"Sani","sequence":"additional","affiliation":[{"name":"Department of Medicine 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