{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T14:48:38Z","timestamp":1776091718137,"version":"3.50.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">High blood pressure (BP) is a well\u2010known risk factor for atrial fibrillation (AF), but a single BP measurement may provide limited information about AF risk in older adults.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">This study included 1256 MESA (Multi\u2010Ethnic Study of Atherosclerosis) and 1948 ARIC (Atherosclerosis Risk in Communities) study participants who underwent extended ambulatory electrocardiographic monitoring and who were free of clinically detected cardiovascular disease, including AF. Using BP measurements from 6 examinations (2000\u20132018 in MESA and 1987\u20132017 in ARIC study), we calculated individual long\u2010term mean, trend, and detrended visit\u2010to\u2010visit variability in systolic BP and pulse pressure for each participant. Outcomes, assessed at examination 6, included subclinical AF and supraventricular ectopy. Results from each study were combined with inverse variance\u2010weighted meta\u2010analysis. At examination 6, the mean age was 73\u00a0years in MESA and 79\u00a0years in ARIC study, and 4% had subclinical AF. Higher visit\u2010to\u2010visit detrended variability in systolic BP was associated with a greater prevalence of subclinical AF (odds ratio [OR], 1.20; 95% CI, 1.02\u20131.38) and with more premature atrial contractions\/hour (geometric mean ratio, 1.08; 95% CI, 1.01\u20131.15). For pulse pressure as well, higher visit\u2010to\u2010visit detrended variability was associated with a greater prevalence of AF (OR, 1.18; 95% CI, 1.00\u20131.37). In addition, higher long\u2010term mean pulse pressure was associated with a greater prevalence of subclinical AF (OR, 1.36; 95% CI, 1.08\u20131.70).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Antecedent visit\u2010to\u2010visit variability in systolic BP and pulse pressure, but not current BP, is associated with a higher prevalence of subclinical atrial arrhythmias. Prior longitudinal BP assessment, rather than current BP, may be more helpful in identifying older adults who are at higher risk of atrial arrhythmias.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.020260","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T15:01:00Z","timestamp":1621522860000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Longitudinal Measures of Blood Pressure and Subclinical Atrial Arrhythmias: The MESA and the ARIC Study"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9460-9399","authenticated-orcid":false,"given":"Barbara N.","family":"Harding","sequence":"first","affiliation":[{"name":"Barcelona Institute of Global Health Barcelona Spain"},{"name":"Cardiovascular Health Research Unit Seattle 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S.","family":"Floyd","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit Seattle WA"},{"name":"Department of Epidemiology University of Washington Seattle WA"},{"name":"Department of Medicine Services University of Washington Seattle WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0700-814X","authenticated-orcid":false,"given":"Lin Yee","family":"Chen","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Department of Medicine University of Minnesota Medical School Minneapolis 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