{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:47:39Z","timestamp":1775638059426,"version":"3.50.1"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,8,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Guideline\u2010based cardioprotective medical therapy is intended to reduce the burden of adverse cardiovascular and limb outcomes in patients with peripheral artery disease (PAD). However, contemporary data describing trends in use of medication remains limited. The present study, therefore, aims to investigate changes in use of cardioprotective medication in PAD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">By using Danish national healthcare registries, we identified all patients with first\u2010time diagnosis of PAD (1997\u20132016) and classified them into two groups: (1) PAD+ that includes all patients with PAD with a history of cardiovascular disease, ie, myocardial infarction, atrial fibrillation, and stroke (n=162\u00a0627); and (2) PAD (n=87\u00a0935) that comprise patients without a history of cardiovascular disease. We determined the use of medication in the first 12\u00a0months after the incident diagnosis of PAD and estimated age standardized 1\u2010year mortality rates. Our results showed increase in use of cardioprotective medication throughout the study period in both groups. However, PAD+ had a higher use of medication (acetylsalicylic acid, 3.5%\u201348.4%; Clopidogrel, 0%\u201317.6%; vitamin K antagonists, 0.9%\u20137.8%; new oral anticoagulants, 0.0%\u201310.1%; Statins, 1.9%\u201358.1%; angiotensin\u2010converting enzyme inhibitors, 1.2%\u201320.6%), compared with PAD (acetylsalicylic acid, 2.9%\u201354.4%; Clopidogrel, 0%\u201311.9%; vitamin K antagonists, 0.9%\u20132.4%; new oral anticoagulants, 0.0%\u20133.4%; Statins, 1.5%\u201356.9%; angiotensin\u2010converting enzyme, 0.9%\u201317.2%), respectively. Furthermore, 1\u2010year mortality rates in PAD declined with increased use of medications during study.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In this nationwide study, use of cardioprotective medication increased considerably with time, but compared to patients with other atherosclerotic diseases, there remains an underuse of guideline\u2010based medical therapy in patients with PAD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.020333","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T08:57:23Z","timestamp":1627462643000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Trends in Use of Cardioprotective Medication in Peripheral Artery Disease: A Nationwide Study"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9370-8870","authenticated-orcid":false,"given":"Sadaf","family":"Kamil","sequence":"first","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital Herlev\u2010Gentofte Hellerup Denmark"},{"name":"Department of Cardiology Bispebjerg\u2010Frederiksberg University Hospital Copenhagen Denmark"},{"name":"Department of Biomedicine Copenhagen University Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0564-0237","authenticated-orcid":false,"given":"Thomas S. 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