{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:05:03Z","timestamp":1791385503377,"version":"4.3.3"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,8,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients with acute myocardial infarction (MI), cardioprotective effects of obstructive sleep apnea are postulated on account of hypoxemic preconditioning. The aim of this single\u2010center substudy was to investigate a potential association between obstructive sleep apnea and the presence of coronary collaterals in patients with first\u2010time acute MI who have been enrolled in an ongoing, multicenter clinical trial.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In TEAM\u2010ASV I (Treatment of Sleep Apnea Early After Myocardial Infarction With Adaptive Servo\u2010Ventilation Trial; NCT02093377) patients with first acute MI who received a coronary angiogram within 24\u00a0hours after onset of symptoms underwent polygraphy within the first 3\u00a0days. Coronary collaterals were classified visually by assigning a Cohen\u2010Rentrop Score (CRS) ranging between 0 (no collaterals) and 3. Of 94 analyzed patients, 14% had significant coronary collaterals with a CRS \u22652. Apnea\u2010Hypopnea Index (AHI) score was significantly higher in patients with CRS \u22652 compared with those with CRS &lt;2 (31\/hour [11\u201354] versus 13\/hour [4\u201327];\n              <jats:italic>P<\/jats:italic>\n              =0.032). A multivariable regression model revealed a significant association between obstructive AHI and CRS \u22652 that was independent of age, sex, body mass index, and culprit lesion left anterior descending artery (odds ratio [OR], 1.06; 95% CI, 1.01\u20131.12;\n              <jats:italic>P<\/jats:italic>\n              =0.023), but no significant association between coronary collaterals and central AHI (OR, 1.02; 95% CI, 0.97\u20131.08;\n              <jats:italic>P<\/jats:italic>\n              =0.443).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Patients with first\u2010time acute MI had more extensive coronary collateralization with an increased AHI or rather an increased obstructive AHI. This finding supports the hypothesis that obstructive sleep apnea exerts potential cardioprotective effects, in addition to its known deleterious effects, in patients with acute MI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT02093377.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.020340","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T08:51:28Z","timestamp":1627635088000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Occurrence of Coronary Collaterals in Acute Myocardial Infarction and Sleep Apnea"],"prefix":"10.1161","volume":"10","author":[{"given":"Verena","family":"Summerer","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II University Hospital Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Arzt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II University Hospital Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2187-8715","authenticated-orcid":false,"given":"Henrik","family":"Fox","sequence":"additional","affiliation":[{"name":"Clinic for General and Interventional Cardiology\/Angiology Heart and Diabetes Center NRW Ruhr University Bochum Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Oldenburg","sequence":"additional","affiliation":[{"name":"Clinic for General and Interventional Cardiology\/Angiology Heart and Diabetes Center NRW Ruhr University Bochum Bad Oeynhausen Germany"},{"name":"Clinic for Cardiology Clemens Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Zeman","sequence":"additional","affiliation":[{"name":"Center for Clinical Studies, Biostatistics University Hospital Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Debl","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II University Hospital Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Buchner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II University Hospital Regensburg Regensburg Germany"},{"name":"Internal Medicine II \u2013 Cardiology Sana Clinics of the District of Cham Cham Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8783-618X","authenticated-orcid":false,"given":"Stefan","family":"Stadler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II University Hospital Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2015.03.032"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht450"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11818-018-0154-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11818-019-0197-5"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-012-0770-7"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2005.10.033"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.4172\/2325-9639.1000109"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201206-1144OC"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1136"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ancard.2015.01.014"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-020-4091-z"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.87.6.520"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvaa158"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11818-020-00243-y"},{"key":"e_1_3_2_16_2","unstructured":"Berry R Brooks R Gamaldo C Harding SM Lloyd RM Marcus CL Vaughn BV. 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