{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T21:10:37Z","timestamp":1780693837170,"version":"3.54.1"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,7,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">We describe calendar time trends of patients with simple congenital heart disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Using the nationwide Danish registries, we identified individuals diagnosed with isolated ventricular septal defect, atrial septal defect, patent ductus arteriosus, or pulmonary stenosis during 1977 to 2015, who were alive at 5\u00a0years of age. We reported incidence per 1\u00a0000\u00a0000 person\u2010years with 95% CIs, 1\u2010year invasive cardiac procedure probability and age at time of diagnosis stratified by diagnosis age (children \u226418 years, adults &gt;18\u00a0years), and 1\u2010year all\u2010cause mortality stratified by diagnosis age groups (5\u201330, 30\u201360, 60+ years). We identified 15\u00a0900 individuals with simple congenital heart disease (ventricular septal defect, 35.2%; atrial septal defect, 35.0%; patent ductus arteriosus, 25.2%; pulmonary stenosis, 4.6%), of which 75.7% were children. From 1977 to 1986 and 2007 to 2015, the incidence rates increased for atrial septal defect in adults (8.8 [95% CI, 7.1\u201310.5] to 31.8 [95% CI, 29.2\u201334.5]) and in children (26.6 [95% CI, 20.9\u201332.3] to 150.8 [95% CI, 126.5\u2013175.0]). An increase was only observed in children for ventricular septal defect (72.1 [95% CI, 60.3\u201383.9] to 115.4 [95% CI, 109.1\u2013121.6]), patent ductus arteriosus (49.2 [95% CI, 39.8\u201358.5] to 102.2 [95% CI, 86.7\u2013117.6]) and pulmonary stenosis (5.7 [95% CI, 3.0\u20138.3] to 21.5 [95% CI, 17.2\u201325.7]) while the incidence rates remained unchanged for adults. From 1977\u20131986 to 2007\u20132015, 1\u2010year mortality decreased for all age groups (&gt;60\u00a0years, 30.1%\u20139.6%; 30\u201360\u00a0years, 9.5%\u20131.0%; 5\u201330\u00a0years, 1.9%\u20130.0%), and 1\u2010year procedure probability decreased for children (13.8%\u20136.6%) but increased for adults (13.3%\u201329.6%) were observed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Increasing incidence and treatment and decreasing mortality among individuals with simple congenital heart disease point toward an aging and growing population. Broader screening methods for asymptomatic congenital heart disease are needed to initiate timely treatment and follow\u2010up.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.020375","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T13:07:47Z","timestamp":1625317667000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Time Trends in Simple Congenital Heart Disease Over 39 Years: A Danish Nationwide Study"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6022-1380","authenticated-orcid":false,"given":"Mohamad","family":"El\u2010Chouli","sequence":"first","affiliation":[{"name":"Danish Heart Foundation Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00edmur H\u00f8gnason","family":"Mohr","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev and Gentofte Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casper N.","family":"Bang","sequence":"additional","affiliation":[{"name":"Danish Heart Foundation Copenhagen Denmark"},{"name":"Department of Cardiology Bispebjerg and Frederiksberg Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4838-2031","authenticated-orcid":false,"given":"Morten","family":"Malmborg","sequence":"additional","affiliation":[{"name":"Danish Heart Foundation Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Ahlehoff","sequence":"additional","affiliation":[{"name":"Department of Cardiology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2892-6131","authenticated-orcid":false,"given":"Christian","family":"Torp\u2010Pedersen","sequence":"additional","affiliation":[{"name":"Departments of Clinical Investigation and Cardiology North Zealand University Hospital Hiller\u00f8d Denmark"},{"name":"Department of Cardiology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Gerds","sequence":"additional","affiliation":[{"name":"Danish Heart Foundation Copenhagen Denmark"},{"name":"Section of Biostatistics University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Idorn","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Rauns\u00f8","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev and Gentofte Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0548-402X","authenticated-orcid":false,"given":"Gunnar","family":"Gislason","sequence":"additional","affiliation":[{"name":"Danish Heart Foundation Copenhagen Denmark"},{"name":"Department of Cardiology Herlev and Gentofte Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.025"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq249"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000602"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.03.587"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.05.046"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx687"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.10.015"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.017226"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.10.017"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_3_1_13_2","volume-title":"Language and Environment for Statistical Computing","author":"R Core Team. 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