{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:18:26Z","timestamp":1791317906713,"version":"4.3.1"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,6,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Left atrial appendage (LAA) morphology predicts stroke risk in patients with atrial fibrillation. However, it is not precisely understood how LAA morphology influences stroke risk. The present study aimed to investigate the relationship between LAA morphology and local thrombogenesis\u2010related blood parameters in LAA.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We enrolled 205 patients undergoing catheter ablation of atrial fibrillation. The prevalence of chicken wing\u2013, cactus\u2010, windsock\u2010, and cauliflower\u2010type LAAs were 23.9%, 32.7%, 29.3%, and 14.1%, respectively. Blood samples were collected from the femoral vein, left atrium, and LAA in each patient. The levels of blood parameters were tested for each blood sample. The cauliflower\u2010type LAA was associated with elevated platelet P\u2010selectin expression, and interleukin\u20106 levels and with lower NO levels in LAA blood samples (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) independent of LAA flow velocity and LAA volume. LAA flow velocity, which was lowest in the cauliflower\u2010type LAA, was the only independent predictor of von Willebrand factor antigen and plasminogen activator inhibitor\u20101 levels in LAA blood samples. In femoral vein blood samples, no significant difference was detected in the above blood parameters among the four LAA morphological types. In all blood samples, the levels of thrombin\u2010antithrombin complex, D\u2010dimer, fibrinogen, and tissue plasminogen activator were comparable among the four LAA morphological types.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients with atrial fibrillation, LAA morphological types might be associated with local platelet activity, fibrinolysis function, endothelial dysfunction, and inflammation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.020406","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T09:16:18Z","timestamp":1622884578000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Left Atrial Appendage Morphology and Local Thrombogenesis\u2010Related Blood Parameters in Patients With Atrial Fibrillation"],"prefix":"10.1161","volume":"10","author":[{"given":"Buyun","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Cardiology Shaoxing People's Hospital, Shaoxing Hospital, Zhejiang University School of Medicine Zhejiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Neurology Shaoxing People's Hospital, Shaoxing Hospital, Zhejiang University School of Medicine Zhejiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shaoxing People's Hospital, Shaoxing Hospital, Zhejiang University School of Medicine Zhejiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shaoxing People's Hospital, Shaoxing Hospital, Zhejiang University School of Medicine Zhejiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shaoxing People's Hospital, Shaoxing Hospital, Zhejiang University School of Medicine Zhejiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengkai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shaoxing People's Hospital, Shaoxing Hospital, Zhejiang University School of Medicine Zhejiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Shaoxing University Zhejiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqing","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Shaoxing University Zhejiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6293-7136","authenticated-orcid":false,"given":"Yangbo","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shaoxing People's Hospital, Shaoxing Hospital, Zhejiang University School of Medicine Zhejiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-316977"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.04.032"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12710"},{"key":"e_1_3_1_5_2","first-page":"59","article-title":"Correlation between left atrial appendage morphology and flow velocity in patients with paroxysmal atrial fibrillation","volume":"17","author":"Fukushima K","year":"2015","unstructured":"Fukushima K, Fukushima N, Kato K, Ejima K, Sato H, Fukushima K, Saito C, Hayashi K, Arai K, Manaka T, et al. Correlation between left atrial appendage morphology and flow velocity in patients with paroxysmal atrial fibrillation. Eur Heart J Cardiovasc Imaging. 2015;17:59\u201366. 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Annu Int Conf IEEE Eng Med Biol Soc. 2020;2020:2565\u20132568.","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.590018"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.020406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:01:41Z","timestamp":1715598101000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.020406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,15]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,6,15]]}},"alternative-id":["10.1161\/JAHA.120.020406"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.020406","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,15]]},"assertion":[{"value":"2020-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e020406"}}