{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:30:19Z","timestamp":1788849019907,"version":"build-2803163510"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,7,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The aim of this study was to evaluate long\u2010term survival and freedom from coronary artery reintervention after the arterial switch operation (ASO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      This single\u2010center nationwide retrospective study included consecutive children who underwent ASO between 1990 and 2016 (n=605). Long\u2010term outcomes were obtained by cross\u2010mapping individual data with the National Death Registry and the National Registry of Cardiovascular Interventions for adults. A control group was randomly retrieved at a 1:10 ratio from the National Birth and Death Registries. Early mortality was 3.3% and late mortality was 1.7% during a median follow\u2010up of 10 (interquartile range, 5\u201316) years. The probability of overall survival at 20\u00a0years after ASO was 94.9% compared with 99.5% in the background population (hazard ratio [HR] 15.6; 95% CI, 8.9\u201327.5,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Independent multivariable predictors of worse survival were an intramural coronary artery (HR, 5.2; 95% CI, 1.8\u201315.2,\n                      <jats:italic>P<\/jats:italic>\n                      =0.002) and period of ASO 1990 to 1999 (HR, 4.6; 95% CI, 1.5\u201313.6,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Fourteen patients (2.3%) required 16 coronary artery reoperations. Freedom from coronary artery reintervention at 20\u00a0years after ASO was 96%. The only independent multivariable predictor associated with a higher hazard for coronary artery reintervention was an intramural coronary artery (HR, 33.9; 95% CI, 11.8\u201397.5,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Long\u2010term survival after ASO is excellent. Coronary artery reinterventions are rare. An intramural coronary artery was an independent predictor associated with a higher risk for coronary artery reintervention and death, regardless of the surgical period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.120.020479","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T05:08:32Z","timestamp":1624597712000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Long\u2010Term Survival and Freedom From Coronary Artery Reintervention After Arterial Switch Operation for Transposition of the Great Arteries: A Population\u2010Based Nationwide Study"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2993-1557","authenticated-orcid":false,"given":"Karel","family":"Koubsk\u00fd","sequence":"first","affiliation":[{"name":"Children's Heart Centre Second Faculty of Medicine Charles University in Prague and Motol University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Gebauer","sequence":"additional","affiliation":[{"name":"Children's Heart Centre Second Faculty of Medicine Charles University in Prague and Motol University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0388-2390","authenticated-orcid":false,"given":"Tom\u00e1\u0161","family":"Tl\u00e1skal","sequence":"additional","affiliation":[{"name":"Children's Heart Centre Second Faculty of Medicine Charles University in Prague and Motol University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Mat\u011bjka","sequence":"additional","affiliation":[{"name":"Children's Heart Centre Second Faculty of Medicine Charles University in Prague and Motol University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7810-8922","authenticated-orcid":false,"given":"Rudolf","family":"Poruban","sequence":"additional","affiliation":[{"name":"Children's Heart Centre Second Faculty of Medicine Charles University in Prague and Motol University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4543-8279","authenticated-orcid":false,"given":"Denisa","family":"Ji\u010d\u00ednsk\u00e1","sequence":"additional","affiliation":[{"name":"Children's Heart Centre Second Faculty of Medicine Charles University in Prague and Motol University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohumil","family":"Hu\u010d\u00edn","sequence":"additional","affiliation":[{"name":"Children's Heart Centre Second Faculty of Medicine Charles University in Prague and Motol University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4932-1150","authenticated-orcid":false,"given":"Jan","family":"Janou\u0161ek","sequence":"additional","affiliation":[{"name":"Children's Heart Centre Second Faculty of Medicine Charles University in Prague and Motol University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2942-9575","authenticated-orcid":false,"given":"V\u00e1clav","family":"Chaloupeck\u00fd","sequence":"additional","affiliation":[{"name":"Children's Heart Centre Second Faculty of Medicine Charles University in Prague and Motol University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","first-page":"461","article-title":"Successful anatomic correction of transposition of the great vessels. 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