{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:33:57Z","timestamp":1753889637981,"version":"3.41.2"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,8,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Suprasternal access is an alternative access strategy for transcatheter aortic valve replacement (TAVR) where the innominate artery is cannulated from an incision above the sternal notch. To date, suprasternal access has never been compared with transfemoral TAVR. Thus, we sought to assess safety, feasibility, and early clinical outcomes between suprasternal and transfemoral access for patients undergoing TAVR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We evaluated patients from 2 institutional prospective, observational registries containing 1348 patients. Patients were selected in a 2:1 ratio (transfemoral:suprasternal) on the basis of propensity score matching. The primary outcome was in\u2010hospital mortality, and secondary outcomes included the incidence of ischemic stroke, major bleeding, vascular injury, left bundle\u2010branch block, and permanent pacemaker implantation at 30\u2010day follow\u2010up. Propensity score matching identified 89 patients undergoing suprasternal TAVR and 159 patients undergoing transfemoral TAVR suitable for analysis. There was no significant difference between suprasternal TAVR and transfemoral TAVR with respect to in\u2010hospital mortality (1.1% versus 0.6%; odds ratio [OR], 1.80; 95% CI, 0.11\u201329.06;\n              <jats:italic>P<\/jats:italic>\n              =0.680). No patients in either cohort suffered an ischemic stroke. The incidence of major bleeding (2.2% versus 2.5%; OR, 0.89; 95% CI, 0.16\u20134.96;\n              <jats:italic>P<\/jats:italic>\n              =0.895) and vascular injury (1.1% versus 1.9%; OR, 0.59; 95% CI, 0.06\u20135.77;\n              <jats:italic>P<\/jats:italic>\n              =0.651) did not differ significantly. The frequency of left bundle\u2010branch block (9.4% versus 15.8%; OR, 0.56; 95% CI, 0.24\u20131.30;\n              <jats:italic>P<\/jats:italic>\n              =0.177) and permanent pacemaker implantation (11.2% versus 5.9%; OR, 2.01; 95% CI, 0.75\u20135.45;\n              <jats:italic>P<\/jats:italic>\n              =0.169) were not statistically significantly different.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Suprasternal TAVR was safe and achieved promising short\u2010term clinical outcomes when compared with transfemoral TAVR. Future studies seeking to identify the optimal alternative access site should evaluate suprasternal TAVR access alongside other substitutes for transfemoral TAVR.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.020491","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T09:01:28Z","timestamp":1628672488000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Suprasternal Versus Transfemoral Access for Transcatheter Aortic Valve Replacement: Insights From a Propensity Score Matched Analysis"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2606-055X","authenticated-orcid":false,"given":"Michael I.","family":"Brener","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Medicine College of Physicians and Surgeons of Columbia University New York Presbyterian Hospital New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Olds","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Southern California Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Nemeth","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery Department of Surgery College of Physicians and Surgeons of Columbia University New York Presbyterian Hospital New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2681-9885","authenticated-orcid":false,"given":"Paul","family":"Kurlansky","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery Department of Surgery College of Physicians and Surgeons of Columbia University New York Presbyterian Hospital New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamim M.","family":"Nazif","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine College of Physicians and Surgeons of Columbia University New York Presbyterian Hospital New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5309-6734","authenticated-orcid":false,"given":"Torsten P.","family":"Vahl","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine College of Physicians and Surgeons of Columbia University New York Presbyterian Hospital New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar K.","family":"Khalique","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine College of Physicians and Surgeons of Columbia University New York Presbyterian Hospital New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadira B.","family":"Hamid","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine College of Physicians and Surgeons of Columbia University New York Presbyterian Hospital New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amisha","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine College of Physicians and Surgeons of Columbia University New York Presbyterian Hospital New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian G.","family":"Ng","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine College of Physicians and Surgeons of Columbia University New York Presbyterian Hospital New York 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Department of Surgery University of Alabama\u2010Birmingham AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin B.","family":"Leon","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine College of Physicians and Surgeons of Columbia University New York Presbyterian Hospital New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susheel","family":"Kodali","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine College of Physicians and Surgeons of Columbia University New York Presbyterian Hospital New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle W.","family":"Eudailey","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery Department of Surgery University of Alabama\u2010Birmingham 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Results of transcarotid compared with transfemoral transcatheter aortic valve replacement. J Thorac Cardiovasc Surg. 2020:S0022\u20135223(20)30790\u2010X. 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