{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:52:06Z","timestamp":1772171526195,"version":"3.50.1"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,10,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Diuretics are used to manage congestive heart failure in infants with congenital heart disease. Adult data indicate that preoperative diuretic use increases the risk of cardiac surgery associated acute kidney injury (CS\u2010AKI). We have sought to understand if preoperative diuretics in infants increases the risk of CS\u2010AKI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This is a single\u2010center retrospective study of infants (1\u201312\u00a0months) who had CS requiring cardiopulmonary bypass between 2013 and 2018. The diagnosis and severity of CS\u2010AKI was defined according to the Kidney Disease Improving Global Outcomes guidelines. Three hundred patients were included (mean 6\u00a0months, SD 2.4, range 1.2\u201312.9\u00a0months). A total of 149 (49.7%) patients were diagnosed with CS\u2010AKI (stage 1: 80 [54%], stage 2: 57 [38%], stage 3: 12 [8%]). Logistic regression analysis showed preoperative diuretics were not associated with CS\u2010AKI (odds ratio [OR], 0.79; 95% CI, 0.43\u20131.44;\n              <jats:italic>P<\/jats:italic>\n              =0.45). A diagnosis of tetralogy of Fallot was an independent risk factor for CS\u2010AKI (OR, 3.49; 95% CI, 1.33\u20139.1,\n              <jats:italic>P<\/jats:italic>\n              =0.01). A diagnosis of tetralogy of Fallot (OR, 3.6; 95% CI, 1.28\u201310.22;\n              <jats:italic>P<\/jats:italic>\n              =0.02) and longer cardiopulmonary bypass (OR, 1.01; 95% CI, 1.0\u20131.02;\n              <jats:italic>P<\/jats:italic>\n              =0.04) time are risk factors for moderate to severe CS\u2010AKI.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Preoperative diuretic use does not contribute to the risk of CS\u2010AKI in infants early after surgery. A diagnosis of tetralogy of Fallot was the only risk factor for CS\u2010AKI identified using multivariate analysis in our cohort. Furthermore, a diagnosis of tetralogy of Fallot and longer cardiopulmonary bypass time are risk factors for moderate to severe CS\u2010AKI.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.020519","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T09:10:12Z","timestamp":1633684212000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Association of Preoperative Diuretic Use With Early Acute Kidney Injury in Infants With Biventricular Hearts Following Cardiac Surgery"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4132-5613","authenticated-orcid":false,"given":"Steven L.","family":"Rathgeber","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics Faculty of Medicine University of British Columbia Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrija","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics Faculty of Medicine University of British Columbia Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Kapravelou","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics Faculty of Medicine University of British Columbia Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Hemphill","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics Faculty of Medicine University of British Columbia Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Voss","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine University of British Columbia Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cherry","family":"Mammen","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Pediatrics Faculty of Medicine University of British Columbia Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Skippen","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine Department of Pediatrics Faculty of Medicine University of British Columbia Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin C.","family":"Harris","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics Faculty of Medicine University of British Columbia Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-013-2454-3"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/2150135115623289"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3643-2"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.02.021"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2017.09.007"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.10.048"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31821201d3"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-17-0075"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.paed.2017.01.008"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2017.01.001"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2013.08.008"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-016-0205-1"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12024"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2009.06228.x"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.119064"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2004.03.027"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.2"},{"key":"e_1_3_1_19_2","first-page":"1","article-title":"Kidney international","volume":"2","author":"Kellum JA","year":"2015","unstructured":"Kellum JA, Lameire N. Kidney international. Kidney Int Suppl. 2015;2:1\u2013138.","journal-title":"Kidney Int Suppl"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.020519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:57:50Z","timestamp":1715597870000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.020519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,19]]},"references-count":18,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2021,10,19]]}},"alternative-id":["10.1161\/JAHA.120.020519"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.020519","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,19]]},"assertion":[{"value":"2020-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e020519"}}