{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T15:28:06Z","timestamp":1783783686530,"version":"3.55.0"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,9,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Testosterone treatment is common in men, although risks for major cardiovascular events are unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">A study was conducted in US male veterans, aged \u226540\u00a0years, with low serum testosterone and multiple medical comorbidities and without history of myocardial infarction, stroke, venous thromboembolism, prostate cancer, or testosterone treatment in the prior year. For the primary outcome, we examined if testosterone treatment was associated with a composite cardiovascular outcome (incident myocardial infarction, ischemic stroke, or venous thromboembolism). Testosterone use was modeled as intramuscular or transdermal and as current use, former use, and no use. Current testosterone users were compared with former users to reduce confounding by indication. The cohort consisted of 204\u00a0857 men with a mean (SD) age of 60.9 (9.9) years and 4.7 (3.5) chronic medical conditions. During follow\u2010up of 4.3 (2.8) years, 12\u00a0645 composite cardiovascular events occurred. In adjusted Cox regression analyses, current use of transdermal testosterone was not associated with risk for the composite cardiovascular outcome (hazard ratio [HR], 0.89; 95% CI, 0.76\u20131.05) in those without prevalent cardiovascular disease, and in those with prevalent cardiovascular disease was associated with lower risk (HR, 0.80; 95% CI, 0.70\u20130.91). In similar analyses, current use of intramuscular testosterone was not associated with risk for the composite cardiovascular outcome in men without or with prevalent cardiovascular disease (HR, 0.91; 95% CI, 0.80\u20131.04; HR, 0.98; 95% CI, 0.89\u20131.09, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In a large cohort of men without a history of myocardial infarction, stroke, or venous thromboembolism, testosterone treatment was not associated with increased risk for incident composite cardiovascular events.<\/jats:p>\n                  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Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Korpak","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System (VAPSHCS) Seattle WA"},{"name":"Seattle Epidemiologic Research and Information Center (ERIC) VAPSHCS Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Krakauer","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Washington Health Research Institute Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Forsberg","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System (VAPSHCS) Seattle WA"},{"name":"Seattle Epidemiologic Research and Information Center (ERIC) VAPSHCS Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra E.","family":"Fox","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System (VAPSHCS) Seattle 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