{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:51:48Z","timestamp":1790290308178,"version":"4.1.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,8,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The impact of staged versus concomitant coronary procedures on renal function in patients with aortic stenosis undergoing transcatheter aortic valve implantation (TAVI) remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Three\u2010hundred thirty\u2010nine patients undergoing coronary procedures and TAVI as a staged strategy (160, 47.2%) or concomitant strategy (179, 52.8%) were retrospectively analyzed. Contrast\u2010induced acute kidney injury (CI\u2010AKI) occurred in 49 patients in the staged strategy group (30.6%) and in 18 patients (10.1%) in the concomitant strategy group (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Among the staged strategy group, 25 (15.6%) patients developed CI\u2010AKI after coronary angiography or percutaneous coronary intervention, 17 (10.6%) after TAVI, and 7 (4.3%) after both the procedures. Staged strategy was associated with a higher risk of CI\u2010AKI (odds ratio, 3.948;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001) after adjustment for multiple confounders and regardless of the baseline renal function (\n                      <jats:italic>P<\/jats:italic>\n                      for interaction=0.4) when compared with the concomitant strategy. At a median follow\u2010up of 24.0\u00a0months (3.0\u201335.3), CI\u2010AKI was not associated with sustained renal injury (\n                      <jats:italic>P<\/jats:italic>\n                      =0.794), irrespective of the adopted strategy. The concomitant strategy did not impact the overall early safety at 30\u00a0days follow\u2010up after TAVI compared to the staged strategy (\n                      <jats:italic>P<\/jats:italic>\n                      =0.609).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Performing coronary procedures with a staged strategy before TAVI was associated with a higher risk of CI\u2010AKI compared with a concomitant strategy. Moreover, a concomitant strategy did not increase the risk of procedure\u2010related complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.120.020599","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T13:16:16Z","timestamp":1627305376000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Contrast\u2010Induced Nephropathy in Patients Undergoing Staged Versus Concomitant Transcatheter Aortic Valve Implantation and Coronary Procedures"],"prefix":"10.1161","volume":"10","author":[{"given":"Gabriele","family":"Venturi","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Pighi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Lunardi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mainardi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3638-200X","authenticated-orcid":false,"given":"Paolo Alberto","family":"Del Sole","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Tavella","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Setti","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Pesarini","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1216-5369","authenticated-orcid":false,"given":"Annachiara","family":"Benini","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Ferrero","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5916-8882","authenticated-orcid":false,"given":"Roberto","family":"Scarsini","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6662-0304","authenticated-orcid":false,"given":"Flavio","family":"Ribichini","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1700456"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.012618","article-title":"Physiological versus angiographic guidance for myocardial revascularization in patients undergoing transcatheter aortic valve implantation","author":"Lunardi M","year":"2019","unstructured":"Lunardi M , Scarsini R , Venturi G , Pesarini G , Pighi M , Gratta A , Gottin L , Barbierato M , Caprioglio F , Piccoli A , et al. 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