{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:15:29Z","timestamp":1792818929116,"version":"4.5.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,10,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Although the association between dysregulated coagulation and atherosclerosis is well recognized, individual assays have been of minimal value in understanding disease susceptibility. Here we investigated the association of global coagulation profiles with coronary artery disease with consideration of sex differences.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">The study included patients from the BioHEART\u2010CT (The BioHEART Study: Assessing Patients With Suspected Cardiovascular Disease for New Disease Markers and Risk Factors) biobank who had computed tomography coronary angiograms scored for coronary artery calcium score (CACS) and Gensini score. The cohort included 206 adult patients who were referred for clinically indicated computed tomography coronary angiography and had a median of 2 major cardiac risk factors; 50% were women and the average age was 62.6 years (\u00b19.9 years). The overall hemostatic potential (OHP) and calibrated automated thrombography generation assays were performed on platelet\u2010poor plasma. CACS and Gensini score in men were significantly correlated in bivariate analysis with measures from the OHP assay, and regression models predicting disease severity by CACS or Gensini score were improved by adding the OHP assay variables in men but not in women. The calibrated automated thrombography generation assay demonstrated a more hypercoagulable profile in women than in men. The OHP assay showed hypercoagulable profiles in women with hyperlipidemia and men with obesity.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The OHP assay identified hypercoagulable profiles associated with different risk factors for each sex and was associated with CACS and Gensini score severity in men, emphasizing the associations between increased fibrin generation and reduced fibrinolysis with cardiac risk factors and early atherosclerosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration Information<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.anzctr.org.au\">www.anzctr.org.au<\/jats:ext-link>\n              . Identifier: ACTRN12618001322224.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.020604","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T10:47:46Z","timestamp":1633690066000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Association of Global Coagulation Profiles With Cardiovascular Risk Factors and Atherosclerosis: A Sex Disaggregated Analysis From the BioHEART\u2010CT Study"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9923-2722","authenticated-orcid":false,"given":"Katharine A.","family":"Kott","sequence":"first","affiliation":[{"name":"Cardiovascular Discovery Group Kolling Institute of Medical ResearchUniversity of Sydney Sydney Australia"},{"name":"Department of Cardiology Royal North Shore Hospital Sydney Australia"},{"name":"Northern Clinical School Faculty of Medicine and Health University of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Christine","family":"Morel\u2010Kopp","sequence":"additional","affiliation":[{"name":"Department of Haematology and Transfusion Medicine Royal North Shore Hospital Sydney Australia"},{"name":"Northern Blood Research Centre Kolling Institute of Medical ResearchUniversity of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6262-0916","authenticated-orcid":false,"given":"Stephen T.","family":"Vernon","sequence":"additional","affiliation":[{"name":"Cardiovascular Discovery Group Kolling Institute of Medical ResearchUniversity of Sydney Sydney Australia"},{"name":"Department of Cardiology Royal North Shore Hospital Sydney Australia"},{"name":"Northern Clinical School Faculty of Medicine and Health University of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Takagi","sequence":"additional","affiliation":[{"name":"Northern Blood Research Centre Kolling Institute of Medical ResearchUniversity of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda A.","family":"Di Bartolo","sequence":"additional","affiliation":[{"name":"Cardiovascular Discovery Group Kolling Institute of Medical ResearchUniversity of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8040-2258","authenticated-orcid":false,"given":"Karlheinz","family":"Peter","sequence":"additional","affiliation":[{"name":"Atherothrombosis and Vascular Biology Laboratory Baker Heart and Diabetes Institute Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5271-2603","authenticated-orcid":false,"given":"Jean Y.","family":"Yang","sequence":"additional","affiliation":[{"name":"Charles Perkins Centre University of Sydney Sydney Australia"},{"name":"School of Mathematics and Statistics University of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart M.","family":"Grieve","sequence":"additional","affiliation":[{"name":"Northern Clinical School Faculty of Medicine and Health University of Sydney Sydney Australia"},{"name":"Department of Radiology Royal Price Alfred Hospital Sydney Australia"},{"name":"Imaging and Phenotyping Laboratory Charles Perkins Centre Faculty of Medicine and Health University of Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4929-1200","authenticated-orcid":false,"given":"Christopher","family":"Ward","sequence":"additional","affiliation":[{"name":"Northern Clinical School Faculty of Medicine and Health University of Sydney Sydney Australia"},{"name":"Department of Haematology and Transfusion Medicine Royal North Shore Hospital Sydney Australia"},{"name":"Northern Blood Research Centre Kolling Institute of Medical ResearchUniversity of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5080-6083","authenticated-orcid":false,"given":"Gemma A.","family":"Figtree","sequence":"additional","affiliation":[{"name":"Cardiovascular Discovery Group Kolling Institute of Medical ResearchUniversity of Sydney Sydney Australia"},{"name":"Department of Cardiology Royal North Shore Hospital Sydney Australia"},{"name":"Northern Clinical School Faculty of Medicine and Health University of Sydney Sydney Australia"},{"name":"Charles Perkins Centre University of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30925-9"},{"key":"e_1_3_2_3_2","unstructured":"Australian Bureau of Statistics . 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