{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T13:03:38Z","timestamp":1769000618681,"version":"3.49.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,9,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Women with chronic hypertension face a 5\u2010 to 6\u2010fold increased risk of developing preeclampsia compared with normotensive women. Angiogenic markers, especially soluble fms\u2010like kinase 1 (sFlt\u20101) and placental growth factor (PlGF), were identified as clinically useful markers predicting the development of preeclampsia, but data on the prediction of superimposed preeclampsia are scarce. Therefore, we aimed to evaluate the predictive value of the sFlt\u20101\/PlGF ratio for delivery because of superimposed preeclampsia in women with chronic hypertension.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This retrospective study included 142 women with chronic hypertension and suspected superimposed preeclampsia. Twenty\u2010seven women (19.0%) delivered because of maternal indications only, 17 women (12.0%) because of fetal indications primarily, and 98 women (69.0%) for other reasons. Women who both delivered because of maternal indications and for fetal indications had a significantly higher sFlt\u20101\/PlGF ratio (median 99.9 and 120.2 versus 7.3, respectively,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 for both) and lower PlGF levels (median 73.6 and 53.3 versus 320.0\u00a0pg\/mL, respectively,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 for both) compared with women who delivered for other reasons. SFlt\u20101\/PlGF ratio and PlGF were strong predictors for delivery because of superimposed preeclampsia, whether for maternal or fetal indications (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05). Half of women with angiogenic imbalance (sFlt\u20101\/PlGF ratio \u226585 or PlGF levels &lt;100\u00a0pg\/mL) delivered because of maternal or fetal indications within 1.6\u00a0weeks (95% CI, 1.0\u20132.4\u00a0weeks).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Angiogenic marker imbalance in women with suspected superimposed preeclampsia can predict delivery because of maternal and fetal indications related to superimposed preeclampsia and is associated with a significantly shorter time to delivery interval.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.020631","type":"journal-article","created":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T09:06:57Z","timestamp":1630141617000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Prognostic Value of Angiogenic Markers in Pregnant Women With Chronic Hypertension"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5725-9270","authenticated-orcid":false,"given":"Julia","family":"Binder","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Feto\u2010Maternal Medicine Medical University of Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2449-2575","authenticated-orcid":false,"given":"Pilar","family":"Palmrich","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Feto\u2010Maternal Medicine Medical University of Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erkan","family":"Kalafat","sequence":"additional","affiliation":[{"name":"Department of Statistics Faculty of Arts and Sciences Middle East Technical University Ankara Turkey"},{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Koc University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Pateisky","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Feto\u2010Maternal Medicine Medical University of Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9206-6856","authenticated-orcid":false,"given":"Ebru","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Mittelberger","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Feto\u2010Maternal Medicine Medical University of Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2802-7670","authenticated-orcid":false,"given":"Asma","family":"Khalil","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit St George's Hospital St George's University of London London United Kingdom"},{"name":"Vascular Biology Research Centre Molecular and Clinical Sciences Research Institute St George's University of London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g2301"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.11.1243"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.02.018"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2018.10.006"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.12.235"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17493"},{"key":"e_1_3_1_8_2","first-page":"S0002\u20109378(20)3","article-title":"Toward personalized management of chronic hypertension in pregnancy","volume":"18","author":"Magee LA","year":"2020","unstructured":"Magee LA, Khalil A, Kametas N, von Dadelszen P. 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