{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:26:15Z","timestamp":1788351975031,"version":"build-2803163510"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,10,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">There is emerging evidence that rosacea, a chronic cutaneous inflammatory disease, is associated with various systemic diseases. However, its association with cardiovascular disease (CVD) remains controversial. We aimed to investigate whether patients with rosacea are at increased risk of developing CVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">This retrospective cohort study from the Korean National Health Insurance Service\u2010Health Screening Cohort included patients with newly diagnosed rosacea (n=2681) and age\u2010, sex\u2010, and index year\u2013matched reference populations without rosacea (n=26\u00a0810) between 2003 and 2014. The primary outcome was subsequent CVD including coronary heart disease and stroke. Multivariable Cox regression analyses were used to evaluate adjusted hazard ratios for subsequent CVD adjusted for major risk factors of CVD. Compared with the reference population (13\u00a0410 women; mean [SD] age, 57.7 [9.2] years), patients with rosacea (1341 women; mean [SD] age, 57.7 [9.2] years) displayed an increased risk for CVD (adjusted hazard ratios, 1.20; 95% CI, 1.03\u20131.40) and coronary heart disease (adjusted hazard ratios, 1.29; 95% CI, 1.05\u20131.60). The risk for stroke was not significantly elevated (adjusted hazard ratios, 1.12; 95% CI, 0.91\u20131.37).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">This study suggests that patients with rosacea are more likely to develop subsequent CVD. Proper education for patients with rosacea to manage other modifiable risk factors of CVD along with rosacea is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.120.020671","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T05:24:06Z","timestamp":1632461046000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Association of Rosacea With Cardiovascular Disease: A Retrospective Cohort Study"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7135-3784","authenticated-orcid":false,"given":"Daein","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Seoul National University Graduate School Seoul South Korea"},{"name":"Department of Medicine Mount Sinai Beth IsraelIcahn School of Medicine at Mount Sinai New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8482-520X","authenticated-orcid":false,"given":"Sungjun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University Hospital Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seulggie","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Seoul National University Graduate School Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7498-4829","authenticated-orcid":false,"given":"Sang Min","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Seoul National University Graduate School Seoul South Korea"},{"name":"Department of Family Medicine Seoul National University Hospital Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1401-2670","authenticated-orcid":false,"given":"Hyun\u2010Sun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Dermatology SMG\u2010SNU Boramae Medical Center Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.037"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11037.x"},{"key":"e_1_3_1_4_2","first-page":"282","article-title":"Incidence and prevalence of rosacea: a systematic review and meta\u2010analysis","volume":"179","author":"Gether L","year":"2018","unstructured":"Gether L, Overgaard LK, Egeberg A, Thyssen JP. 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