{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:43:54Z","timestamp":1778600634378,"version":"3.51.4"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,10,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">A recent study reported that the outcome of patients with plaque erosion treated with stenting is poor when the underlying plaque is lipid rich. However, the detailed phenotype of patients with plaque erosion, particularly as related to different age groups, has not been systematically studied.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Patients with acute coronary syndromes caused by plaque erosion were selected from 2 data sets. Demographic, clinical, angiographic, and optical coherence tomography findings of the culprit lesion were compared between 5 age groups. Among 579 erosion patients, male sex and current smoking were less frequent, and hypertension, diabetes, and chronic kidney disease were more frequent in older patients. ST\u2010segment\u2013elevation myocardial infarction was more frequent in younger patients. Percentage of diameter stenosis on angiogram was greater in older patients. The prevalence of lipid\u2010rich plaque (27.3% in age &lt;45\u00a0years and 49.4% in age \u226575\u00a0years,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), cholesterol crystal (3.9% in age &lt;45\u00a0years and 21.8% in age \u226575\u00a0years,\n              <jats:italic>P<\/jats:italic>\n              =0.027), and calcification (5.5% in age &lt;45\u00a0years and 54.0% in age \u226575\u00a0years,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) increased with age. After adjusting risk factors, younger patients were associated with the presence of thrombus, and older patients were associated with greater percentage of diameter stenosis and the presence of lipid\u2010rich plaque and calcification.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The demographic, clinical, angiographic, and plaque phenotypes of patients with plaque erosion distinctly vary depending on age. This may affect the clinical outcome in these patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifiers: NCT03479723, NCT02041650.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.020691","type":"journal-article","created":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T14:41:25Z","timestamp":1632580885000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Age and Phenotype of Patients With Plaque Erosion"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1540-9672","authenticated-orcid":false,"given":"Makoto","family":"Araki","sequence":"first","affiliation":[{"name":"Cardiology Division Massachusetts General HospitalHarvard Medical School Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1798-5008","authenticated-orcid":false,"given":"Taishi","family":"Yonetsu","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Kurihara","sequence":"additional","affiliation":[{"name":"Cardiology Division Massachusetts General HospitalHarvard Medical School Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4992-2586","authenticated-orcid":false,"given":"Akihiro","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Cardiology Division Massachusetts General HospitalHarvard Medical School Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Lee","sequence":"additional","affiliation":[{"name":"Biostatistics Center Massachusetts General HospitalHarvard Medical School Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5386-584X","authenticated-orcid":false,"given":"Tsunenari","family":"Soeda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Nara Medical University Kashihara Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2745-9682","authenticated-orcid":false,"given":"Yoshiyasu","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kitasato University School of Medicine Sagamihara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Higuma","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine St. Marianna University School of Medicine Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Kimura","sequence":"additional","affiliation":[{"name":"Division of Cardiology Kameda Medical Center Chiba 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