{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T01:04:15Z","timestamp":1786496655959,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,11,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">This study sought to investigate the role of postprocedural troponin elevations in mortality prediction after transcatheter aortic valve implantation and to define the threshold at which clinically relevant postprocedure myocardial injury determines mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 1333 consecutive patients with transcatheter aortic valve implantation with available postprocedural high\u2010sensitivity cardiac troponin T measurements were included in the analysis. The threshold at which postprocedure myocardial injury determines long\u2010term mortality was identified using restricted cubic spline analysis. A &gt;18.3\u2010fold increase of troponin above the upper reference limit was identified as threshold for relevant postprocedure myocardial injury. Associations remained significant in a landmark analysis between 30\u00a0days and 2\u00a0years (hazard ratio [HR], 1.61, [95% CI, 1.13\u20132.28];\n              <jats:italic>P<\/jats:italic>\n              =0.01), after adjusting for known confounders (adjusted HR, 1.90 [95% CI, 1.40\u20132.57];\n              <jats:italic>P<\/jats:italic>\n              &lt;0001), and in subgroups of patients with coronary artery disease (adjusted HR, 2.17 [95% CI, 1.44\u20133.29];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), renal dysfunction (adjusted HR, 1.88 [95% CI, 1.35\u20132.62];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), and intermediate\/high surgical risk (adjusted HR, 2.70 [95% CI, 1.40\u20135.22];\n              <jats:italic>P<\/jats:italic>\n              =0.003).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">This study determined a troponin threshold for the identification of patients at increased mortality risk after transcatheter aortic valve implantation. The proposed definition of postprocedure myocardial injury advances risk stratification in patients with transcatheter aortic valve implantation and may assist in postprocedural patient management.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.020739","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T09:02:53Z","timestamp":1635498173000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Postprocedural Troponin Elevation and Mortality After Transcatheter Aortic Valve Implantation"],"prefix":"10.1161","volume":"10","author":[{"given":"Matthias","family":"Schindler","sequence":"first","affiliation":[{"name":"Cardiology University Heart CenterUniversity Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florin","family":"St\u00f6ckli","sequence":"additional","affiliation":[{"name":"Cardiology University Heart CenterUniversity Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rico","family":"Br\u00fctsch","sequence":"additional","affiliation":[{"name":"Cardiology University Heart CenterUniversity Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2443-6090","authenticated-orcid":false,"given":"Philipp","family":"Jakob","sequence":"additional","affiliation":[{"name":"Cardiology University Heart CenterUniversity Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Holy","sequence":"additional","affiliation":[{"name":"Cardiology University Heart CenterUniversity Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Michel","sequence":"additional","affiliation":[{"name":"Cardiology University Heart CenterUniversity Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Manka","sequence":"additional","affiliation":[{"name":"Cardiology University Heart CenterUniversity Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9649-2940","authenticated-orcid":false,"given":"Paul","family":"Vogt","sequence":"additional","affiliation":[{"name":"Cardiac Surgery University Heart CenterUniversity Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0287-4193","authenticated-orcid":false,"given":"Christian","family":"Templin","sequence":"additional","affiliation":[{"name":"Cardiology University Heart CenterUniversity Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Kasel","sequence":"additional","affiliation":[{"name":"Cardiology University Heart CenterUniversity Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Ruschitzka","sequence":"additional","affiliation":[{"name":"Cardiology University Heart CenterUniversity Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3058-6407","authenticated-orcid":false,"given":"Barbara E.","family":"St\u00e4hli","sequence":"additional","affiliation":[{"name":"Cardiology University Heart CenterUniversity Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69208-8"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.02.093"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90249-Z"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.02.009"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.066"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.008681"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx391"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1400590"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816885"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.11.060"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.12.059"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.111.964882"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2019.12.028"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002430"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.011111"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.118.007106"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY15M02_02"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.01.301"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.05.029"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12208"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.04.044"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.05.047"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1159\/000351438"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25788"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.06.053"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs255"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0912134"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-17-00338"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540300029029"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.052"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.07.045"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.020739","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:56:32Z","timestamp":1715601392000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.020739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,2]]},"references-count":33,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2021,11,2]]}},"alternative-id":["10.1161\/JAHA.120.020739"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.020739","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,2]]},"assertion":[{"value":"2020-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e020739"}}