{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:43:45Z","timestamp":1762508625105,"version":"3.41.2"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,11,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">It is poorly understood why some patients with atrial fibrillation develop heart failure (HF) and others do not. We examined the rate of developing HF in patients with atrial fibrillation with and without first\u2010degree family members with HF or dilated cardiomyopathy (DCM).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Using Danish nationwide registries, patients born after 1942 diagnosed with atrial fibrillation in the period 2005 to 2015 were identified and followed for up to 5\u00a0years. Patients with pre\u2010existing HF, DCM, and\/or ischemic heart disease diagnoses were excluded. Exposure was defined as a first\u2010degree relative with HF or DCM. The rate of developing the composite end point of HF or death, and the components, was estimated with multivariable Cox proportional hazard regression models. We included 10\u00a0605 patients. A total of 17% had a family member with DCM\/HF. Having a family member with HF\/DCM was associated with an increased 5\u2010year risk of the composite of HF\/death (cumulative incidence, 9.2% [95% CI, 7.8\u201310.7] versus 5.6% [95% CI, 5.0\u20136.1]; adjusted hazard ratio [HR] 1.36 [95% CI, 1.13\u20131.64]). (HF 8.4% [95% CI, 7.0\u20139.8] versus 4.5% [95% CI, 4.1\u20135.0]); (adjusted HR, 1.49 [95% CI, 1.22\u20131.82]). However, familial HF\/DCM was not significantly associated with an increased 5\u2010year risk and rate of death (0.8% [95% CI, 0.4\u20131.2] versus 1.1% [95% CI, 0.8\u20131.3]); (adjusted HR, 0.80 [95% CI, 0.46\u20131.39]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients with incident atrial fibrillation without prior ischemic heart disease or HF diagnoses, 1 of 6 had a first\u2010degree relative with HF, and having such a family history of HF\/DCM was associated with an 87% increase in 5\u2010year incidence of HF compared with those without.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.021286","type":"journal-article","created":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T12:40:33Z","timestamp":1635597633000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Rate of Heart Failure Following Atrial Fibrillation According to Presence of Family History of Dilated Cardiomyopathy or Heart Failure: A Nationwide Study"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7320-2266","authenticated-orcid":false,"given":"Magnus N.","family":"Ebbesen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Herlev and Gentofte University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8784-9714","authenticated-orcid":false,"given":"Maria","family":"D\u2019Souza","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev and Gentofte University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6019-8627","authenticated-orcid":false,"given":"Charlotte","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev and Gentofte University Hospital Copenhagen Denmark"},{"name":"Department of Medicine Section of Cardiovascular Medicine Boston Medical Center Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7380-4144","authenticated-orcid":false,"given":"Jawad H.","family":"Butt","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9549-7707","authenticated-orcid":false,"given":"Christian","family":"Madelaire","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev and Gentofte University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4209-2778","authenticated-orcid":false,"given":"Tor","family":"Biering\u2010Sorensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev and Gentofte University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Lock\u2010Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev and Gentofte University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9759-7397","authenticated-orcid":false,"given":"Soren Lund","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev and Gentofte University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0548-402X","authenticated-orcid":false,"given":"Gunnar","family":"Gislason","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev and Gentofte University Hospital Copenhagen Denmark"},{"name":"The Danish Heart Foundation Copenhagen Denmark"},{"name":"University of Copenhagen Faculty of Health and Medical Science Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-1466","authenticated-orcid":false,"given":"Lars","family":"Kober","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet Copenhagen Denmark"},{"name":"University of Copenhagen Faculty of Health and Medical Science Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2892-6131","authenticated-orcid":false,"given":"Christian","family":"Torp\u2010Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Investigation and Cardiology Nordsjaellands Hospital Hillerod Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4271-2466","authenticated-orcid":false,"given":"Morten","family":"Schou","sequence":"additional","affiliation":[{"name":"Department of 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