{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:35:00Z","timestamp":1753889700849,"version":"3.41.2"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,9,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Individual blood cell count abnormalities have been associated with cardiovascular disease and increased mortality. In this study, we defined a \u201ccytopenia phenotype,\u201d reflecting bone marrow hypoproliferation, to determine if peripheral blood cytopenia is associated with increased cardiovascular disease and mortality risk.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Study participants were derived from a biracial observational cohort study, REGARDS (Reasons for Geographic and Racial Differences in Stroke), that enrolled 30\u00a0239 Black and White participants aged \u226545\u00a0years between 2003 and 2007. Median follow up was \u22489\u00a0years. The current study included 19\u00a0864 participants from REGARDS study (37.9% men, 40% Black participants) who have complete blood count available at study enrollment. We defined a cytopenia phenotype based on age\u2010, sex\u2010, and race\u2010adjusted lowest fifth percentile of blood counts. Multivariable Cox proportional hazards models estimated the hazard ratios (HR) and 95% CI of cytopenia for mortality and incident cardiovascular disease in adjusted models. Mean age of the study participants was 64\u00a0years (SD:9.7). The prevalence of cytopenia was 1.9% (n=378). Cytopenia was associated with increased risk of all\u2010cause mortality (HR, 1.73; 95% CI, 1.34\u20132.22) and cardiovascular disease mortality (HR, 1.56; 95% CI, 1.11\u20132.29). Cytopenia was associated with stroke risk in Black but not White participants (HR, 1.96 versus 0.86;\n              <jats:italic>P<\/jats:italic>\n              \u2010interaction for race=0.08) and was not associated with coronary heart disease risk.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">We defined a cytopenia phenotype with clinical implications for mortality and stroke risk in a large biracial and geographically diverse population. Whether generated through somatic mutations or decreased organ function, cytopenia was associated with mortality risk and was a race\u2010specific risk factor for stroke.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.020809","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T09:46:12Z","timestamp":1631526372000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Peripheral Blood Cytopenia and Risk of Cardiovascular Disease and Mortality"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5542-4754","authenticated-orcid":false,"given":"Radhika","family":"Gangaraju","sequence":"first","affiliation":[{"name":"Department of Medicine, School of Medicine University of Alabama at Birmingham Birmingham 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