{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:29:43Z","timestamp":1788535783546,"version":"build-2803163510"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,7,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Ultra\u2010high\u2010density mapping enables detailed mechanistic analysis of atrial reentrant tachycardia but has yet to be used to assess circuit conduction velocity (CV) patterns in adults with congenital heart disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Circuit pathways and central isthmus CVs were calculated from consecutive ultra\u2010high\u2010density isochronal maps at 2 tertiary centers over a 3\u2010year period. Circuits using anatomic versus surgical obstacles were considered separately and pathway length &lt;50th percentile identified small circuits. CV analysis was used to derive a novel index for prediction of postablation conduction block. A total of 136 supraventricular tachycardias were studied (60% intra\u2010atrial reentrant, 14% multiple loop). Circuits with anatomic versus surgical obstacles featured longer pathway length (119\u00a0mm; interquartile range [IQR], 80\u2013150 versus 78\u00a0mm; IQR, 63\u201395;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), faster central isthmus CV (0.1\u00a0m\/s; IQR, 0.06\u20130.25 versus 0.07\u00a0m\/s; IQR, 0.05\u20130.10;\n              <jats:italic>P<\/jats:italic>\n              =0.016), faster non\u2010isthmus CV (0.52\u00a0m\/s; IQR, 0.33\u20130.71 versus 0.38\u00a0m\/s; IQR, 0.27\u20130.46;\n              <jats:italic>P<\/jats:italic>\n              =0.009), and fewer slow isochrones (4; IQR, 2.3\u20136.8 versus 6; IQR 5\u20137;\n              <jats:italic>P<\/jats:italic>\n              =0.008). Both central isthmus (\n              <jats:italic>R<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =0.45;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and non\u2010isthmus CV (\n              <jats:italic>R<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =0.71;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) correlated with pathway length, whereas central isthmus CV &lt;0.15\u00a0m\/s was ubiquitous for small circuits. Non\u2010isthmus CV in tachycardia correlated with CV during block validation (\n              <jats:italic>R<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =0.94;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and a validation map to tachycardia conduction time ratio &gt;85% predicted isthmus block in all cases. Over &gt;1\u00a0year of follow\u2010up, arrhythmia\u2010free survival was better for homogeneous CV patterns (90% versus 57%;\n              <jats:italic>P<\/jats:italic>\n              =0.04).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Ultra\u2010high\u2010density mapping\u2010guided CV analysis distinguishes atrial reentrant patterns in adults with congenital heart disease with surgical obstacles producing slower and smaller circuits. Very slow central isthmus CV may be essential for atrial tachycardia maintenance in small circuits, and non\u2010isthmus conduction time in tachycardia appears to be useful for rapid assessment of postablation conduction block.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.020835","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T09:06:00Z","timestamp":1623661560000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Electrophysiological Characteristics of Intra\u2010Atrial Reentrant Tachycardia in Adult Congenital Heart Disease: Implications for Catheter Ablation"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-6693","authenticated-orcid":false,"given":"Ann\u2010Kathrin","family":"Kahle","sequence":"first","affiliation":[{"name":"Division of Cardiology Evangelishces Krankenhaus D\u00fcsseldorf D\u00fcsseldorf Germany"},{"name":"Institute of Neural and Sensory Physiology Heinrich Heine University D\u00fcsseldorfMedical Faculty D\u00fcsseldorf Germany"},{"name":"cardiac Neuro\u2010 and Electrophysiology Research Consortium D\u00fcsseldorf Germany"},{"name":"German Centre for Cardiovascular Research Partner Site Hamburg\/Kiel\/L\u00fcbeck Germany"},{"name":"Clinic for Cardiology University Heart &amp; Vascular CenterUniversity Hospital Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto G.","family":"Gallotti","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of California at Los Angeles Medical Center, Ahmanson\/Adult Congenital Heart Disease Center Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5260-6352","authenticated-orcid":false,"given":"Fares\u2010Alexander","family":"Alken","sequence":"additional","affiliation":[{"name":"Division of Cardiology Evangelishces Krankenhaus D\u00fcsseldorf D\u00fcsseldorf Germany"},{"name":"Institute of Neural and Sensory Physiology Heinrich Heine University D\u00fcsseldorfMedical Faculty D\u00fcsseldorf Germany"},{"name":"cardiac Neuro\u2010 and Electrophysiology Research Consortium D\u00fcsseldorf Germany"},{"name":"German Centre for Cardiovascular Research Partner Site Hamburg\/Kiel\/L\u00fcbeck Germany"},{"name":"Clinic for Cardiology University Heart &amp; Vascular CenterUniversity Hospital Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0217-3960","authenticated-orcid":false,"given":"Christian","family":"Meyer","sequence":"additional","affiliation":[{"name":"Division of Cardiology Evangelishces Krankenhaus D\u00fcsseldorf D\u00fcsseldorf Germany"},{"name":"Institute of Neural and Sensory Physiology Heinrich Heine University D\u00fcsseldorfMedical Faculty D\u00fcsseldorf Germany"},{"name":"cardiac Neuro\u2010 and Electrophysiology Research Consortium D\u00fcsseldorf Germany"},{"name":"German Centre for Cardiovascular Research Partner Site Hamburg\/Kiel\/L\u00fcbeck Germany"},{"name":"Clinic for Cardiology University Heart &amp; Vascular CenterUniversity Hospital Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3089-9005","authenticated-orcid":false,"given":"Jeremy P.","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of California at Los Angeles Medical Center, Ahmanson\/Adult Congenital Heart Disease Center Los Angeles CA"},{"name":"University of California at Los Angeles Cardiac Arrhythmia CenterUCLA Health SystemDavid Geffen School of Medicine at Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.866319"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2001.00017.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.3.1142"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.21037\/cdt.2019.10.02"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14251"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2019.08.001"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2217\/fca-2020-0032"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2020.05.007"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010535"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.116.004510"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.10.031"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.10.029"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.11.027"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.5.699"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1997.tb03638.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12329"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.050363"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.121.020835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:14:47Z","timestamp":1715598887000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.121.020835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,6]]},"references-count":17,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2021,7,6]]}},"alternative-id":["10.1161\/JAHA.121.020835"],"URL":"https:\/\/doi.org\/10.1161\/jaha.121.020835","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,6]]},"assertion":[{"value":"2021-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e020835"}}