{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T17:50:16Z","timestamp":1779126616974,"version":"3.51.4"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"23","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,12,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Pharmacological inhibition of angiogenesis via the vascular endothelial growth factor pathway is an important therapeutic target that prevents tumor growth and the formation of metastases. Although vascular endothelial growth factor inhibitor (VPI) is well understood as a well\u2010defined safety profile, few real\u2010world studies are comparing the incidence, clinical features, and prognosis of the aneurysm and artery dissection.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              To evaluate and compare the links between different VPIs and aneurysm and artery dissection, we identified 634 reports with VPIs in the US Food and Drug Administration Adverse Event Reporting System database ranging between January 2004 to March 2020. We used the reporting odds ratio for the association between the use of VPIs and aneurysm and artery dissection. The reporting odds ratio (3.68, 95%, 2.18\u20126.23) shows that ramucirumab has a stronger correlation than other VPIs. The results show a significant difference in onset time (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The median time to aneurysm and artery dissection was 79.5 (interquartile interval, 19.0\u2013273.5) days after VPI administration. The results also show that VPI\u2010associated aneurysm and artery dissection was reported more often in men (n=336, 59.68% versus n=227, 40.32%), and there were more cases in patients aged between 45 to 74 years than those &lt;45\u00a0years (n=312, 68.12% versus n=18, 3.93%); patients aged \u226575\u00a0years accounted for 27.95% (n=128). Finally, the suspected drugs generally led to 19.98% deaths and 29.81% hospitalizations.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">We identified signals for aneurysm and artery dissection following various VPIs in real\u2010world practice via the Food and Drug Administration Adverse Event Reporting System, which represents the first step for continued pharmacovigilance investigation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.020844","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T19:06:17Z","timestamp":1638299177000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Aneurysm and Artery Dissection Following the Use of Vascular Endothelial Growth Factor Inhibitor: A Real\u2010World Analysis Using a Spontaneous Reporting System"],"prefix":"10.1161","volume":"10","author":[{"given":"Shuyue","family":"Wang","sequence":"first","affiliation":[{"name":"Research Group of Jian Gong on Pharmacoepidemiology and Clinical Drug Evaluation Shenyang Pharmaceutical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingzhu","family":"Chen","sequence":"additional","affiliation":[{"name":"Research Group of Jian Gong on Pharmacoepidemiology and Clinical Drug Evaluation Shenyang Pharmaceutical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Group of Jian Gong on Pharmacoepidemiology and Clinical Drug Evaluation Shenyang Pharmaceutical University Shenyang 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