{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:19:46Z","timestamp":1793398786987,"version":"4.5.0"},"reference-count":135,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,7,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">As transcatheter aortic valve replacement (TAVR) technology expands to healthy and lower\u2010risk populations, the burden and predictors of procedure\u2010related complications including the need for permanent pacemaker (PPM) implantation needs to be identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Digital databases were systematically searched to identify studies reporting the incidence of PPM implantation after TAVR. A random\u2010 and fixed\u2010effects model was used to calculate unadjusted odds ratios (OR) for all predictors. A total of 78 studies, recruiting 31\u00a0261 patients were included in the final analysis. Overall, 6212 patients required a PPM, with a mean of 18.9% PPM per study and net rate ranging from 0.16% to 51%. The pooled estimates on a random\u2010effects model indicated significantly higher odds of post\u2010TAVR PPM implantation for men (OR, 1.16; 95% CI, 1.04\u20131.28); for patients with baseline mobitz type\u20101 second\u2010degree atrioventricular block (OR, 3.13; 95% CI, 1.64\u20135.93), left anterior hemiblock (OR, 1.43; 95% CI, 1.09\u20131.86), bifascicular block (OR, 2.59; 95% CI, 1.52\u20134.42), right bundle\u2010branch block (OR, 2.48; 95% CI, 2.17\u20132.83), and for periprocedural atriorventricular block (OR, 4.17; 95% CI, 2.69\u20136.46). The mechanically expandable valves had 1.44 (95% CI, 1.18\u20131.76), while self\u2010expandable valves had 1.93 (95% CI, 1.42\u20132.63) fold higher odds of PPM requirement compared with self\u2010expandable and balloon\u2010expandable valves, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Male sex, baseline atrioventricular conduction delays, intraprocedural atrioventricular block, and use of mechanically expandable and self\u2010expanding prosthesis served as positive predictors of PPM implantation in patients undergoing TAVR.<\/jats:p>\n                  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