{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:02Z","timestamp":1787018102583,"version":"build-2736575974"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,7,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Visceral adipose tissue (VAT) is associated with incident heart failure (HF) and HF with preserved ejection fraction, yet it is unknown how pericardial and abdominal adiposity affect HF and mortality risks in Black individuals. We examined the associations of pericardial adipose tissue (PAT), VAT, and subcutaneous adipose tissue (SAT) with incident HF hospitalization and all\u2010cause mortality in a large community cohort of Black participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among the 2882 Jackson Heart Study Exam 2 participants without prevalent HF who underwent body computed tomography, we used Cox proportional hazards models to examine associations between computed tomography\u2013derived regional adiposity and incident HF hospitalization and all\u2010cause mortality. Fully adjusted models included demographics and cardiovascular disease risk factors. Median follow\u2010up was 10.6\u00a0years among participants with available VAT (n=2844), SAT (n=2843), and PAT (n=1386). Fully adjusted hazard ratios (95% CIs) of distinct computed tomography\u2013derived adiposity measures (PAT per 10\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      , VAT or SAT per 100\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      ) were as follows: for incident HF, PAT 1.08 (95% CI, 1.02\u20131.14) and VAT 1.04 (95% CI, 1.01\u20131.08); for HF with preserved ejection fraction, PAT 1.13 (95% CI, 1.04\u20131.21) and VAT 1.07 (95% CI, 1.01\u20131.13); for mortality, PAT 1.07 (95% CI, 1.03\u20131.12) and VAT 1.01 (95% CI, 0.98\u20131.04). SAT was not associated with either outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">High PAT and VAT, but not SAT, were associated with incident HF and HF with preserved ejection fraction, and only PAT was associated with mortality in the fully adjusted models in a longitudinal community cohort of Black participants. Future studies may help understand whether changes in regional adiposity improves HF, particularly HF with preserved ejection fraction, risk predictions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT00005485.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.121.020920","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T04:57:01Z","timestamp":1625806621000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["Regional Adiposity and Risk of Heart Failure and Mortality: The Jackson Heart Study"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3545-4267","authenticated-orcid":false,"given":"Vishal N.","family":"Rao","sequence":"first","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham NC"},{"name":"Division of Cardiology Department of Medicine Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Bush","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham NC"},{"name":"Department of Population Health Sciences Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgana","family":"Mongraw\u2010Chaffin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Prevention Wake Forest University School of Medicine Winston\u2010Salem NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5733-1025","authenticated-orcid":false,"given":"Michael E.","family":"Hall","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Mississippi Medical Center Jackson MS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Donald","family":"Clark","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Mississippi Medical Center Jackson MS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8671-7007","authenticated-orcid":false,"given":"Marat","family":"Fudim","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham NC"},{"name":"Division of Cardiology Department of Medicine Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9501-600X","authenticated-orcid":false,"given":"Adolfo","family":"Correa","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Mississippi Medical Center Jackson MS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0389-6434","authenticated-orcid":false,"given":"Bradley G.","family":"Hammill","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham NC"},{"name":"Department of Population Health Sciences Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham NC"},{"name":"Department of Population Health Sciences Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010I","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Mississippi Medical Center Jackson MS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3222-1719","authenticated-orcid":false,"given":"Robert J.","family":"Mentz","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham NC"},{"name":"Division of Cardiology Department of Medicine Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.07.009"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1514009"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2015.12.003"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.6.3.343"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00033.2011"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-014-0192-z"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2011.03.009"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.02.038"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.11.058"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2016.11.001"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.09.041"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2019.09.002"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20135"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.118.005629"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1956"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1378"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0245"},{"key":"e_1_3_2_19_2","first-page":"S6\u201062\u201070","article-title":"Cardiovascular disease event classification in the Jackson Heart Study: methods and procedures","volume":"15","author":"Keku E","year":"2005","unstructured":"Keku E, Rosamond W, Taylor HA, Garrison R, Wyatt SB, Richard M, Jenkins B, Reeves L, Sarpong D. 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