{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:37:31Z","timestamp":1785771451739,"version":"3.56.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,9,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Redo mitral valve surgery is required in up to one\u2010third of patients and is associated with significant mortality and morbidity. Valve\u2010in\u2010valve transcatheter mitral valve replacement (ViV TMVR) is less invasive and could be considered in those at prohibitive surgical risk. Studies on comparative outcomes of ViV TMVR and redo surgical mitral valve replacement (SMVR) remain limited. Our study aimed to investigate the real\u2010world outcomes of the above procedures using the National Inpatient Sample database.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We analyzed National Inpatient Sample data using the\n              <jats:italic>International Classification of Diseases, Tenth Revision, Clinical Modification<\/jats:italic>\n              (\n              <jats:italic>ICD\u201010\u2010CM<\/jats:italic>\n              ) from September 2015 to December 2018. A total of 495 and 2250 patients underwent redo ViV TMVR and SMVR, respectively. The patients who underwent ViV TMVR were older (77 versus 68\u00a0years,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). Adjusted mortality was higher in the redo SMVR group compared with the ViV TMVR group (7.6% versus &lt;2.8%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). Perioperative complications were higher among patients undergoing redo SMVR including blood transfusions (38% versus 7.6%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01) and acute kidney injury (36.7% versus 13.9%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). Cost of care was higher (USD$57\u00a0172 versus USD$52\u00a0579,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01), length of stay was longer (10 versus 3\u00a0days,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01), and discharge to home was lower (20.3% versus 64.6%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01) in the SMVR group compared with the ViV TMVR group.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">ViV TMVR is associated with lower mortality, periprocedural morbidity, and resource use compared with patients undergoing redo SMVR. ViV TMVR may be a viable option for some patients with mitral prosthesis dysfunction. Studies evaluating long\u2010term outcomes and durability of ViV TMVR are needed. A patient\u2010centered approach by the heart team, local institutional expertise, and careful preprocedure planning can help decision\u2010making about the choice of intervention for the individual patient.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.020948","type":"journal-article","created":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T09:14:48Z","timestamp":1630142088000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":36,"title":["Redo Surgical Mitral Valve Replacement Versus Transcatheter Mitral Valve in Valve From the National Inpatient Sample"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8473-8069","authenticated-orcid":false,"given":"Muhammad","family":"Zia Khan","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine West Virginia University Heart &amp; Vascular Institute Morgantown WV"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2754-9397","authenticated-orcid":false,"given":"Salman","family":"Zahid","sequence":"additional","affiliation":[{"name":"Department of Medicine Rochester General Hospital Rochester NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad U.","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine West Virginia University Heart &amp; Vascular Institute Morgantown WV"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4788-8572","authenticated-orcid":false,"given":"Asim","family":"Kichloo","sequence":"additional","affiliation":[{"name":"St. Mary\u2019s of Saginaw Hospital Saginaw MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakeel","family":"Jamal","sequence":"additional","affiliation":[{"name":"St. Mary\u2019s of Saginaw Hospital Saginaw MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Mannan Khan Minhas","sequence":"additional","affiliation":[{"name":"Forrest General Hospital Hattiesburg MS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4850-0309","authenticated-orcid":false,"given":"Waqas","family":"Ullah","sequence":"additional","affiliation":[{"name":"Abington Jefferson Health PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1304-5748","authenticated-orcid":false,"given":"Yasar","family":"Sattar","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine West Virginia University Heart &amp; Vascular Institute Morgantown WV"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7872-3757","authenticated-orcid":false,"given":"Sudarshan","family":"Balla","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine West Virginia University Heart &amp; Vascular Institute Morgantown WV"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.03.086"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613792"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2001.116470"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000079169.15862.13"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.02.014"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-312047"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.08.083"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.7246"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV10I2A42"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.08.004"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.03.011"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivx067"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy590"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.008425"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.17653"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.924613"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27128"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.01.024"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.06.069"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9485247"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2018.03.126"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)00301-4"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29324"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.2974"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.09.015"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivs005"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-020-02254-y"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.07.035"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.08.089"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.005043"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx391"},{"issue":"20","key":"e_1_3_1_33_2","first-page":"32455","article-title":"Outcomes of mitral valve re\u2010replacement for bioprosthetic structural valve deterioration","volume":"0022","author":"Javadikasgari H","year":"2020","unstructured":"Javadikasgari H, Chemtob RA, Gillinov AM, Pettersson GB, Lowry AM, Desai MY, Svensson LG, Blackstone EH, Wierup P. Outcomes of mitral valve re\u2010replacement for bioprosthetic structural valve deterioration. J Thorac Cardiovasc Surg. 2020;S0022\u20135223(20):32455\u201332457. DOI: 10.1016\/j.jtcvs.2020.08.067.","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.121.020948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:44:30Z","timestamp":1715600670000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.121.020948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,7]]},"references-count":32,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2021,9,7]]}},"alternative-id":["10.1161\/JAHA.121.020948"],"URL":"https:\/\/doi.org\/10.1161\/jaha.121.020948","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,7]]},"assertion":[{"value":"2021-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e020948"}}