{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:18:06Z","timestamp":1791728286603,"version":"4.3.4"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,10,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The Predicting Bleeding Complications in Patients Undergoing Stent Implantation and Subsequent Dual Antiplatelet Therapy (PRECISE\u2010DAPT) score has been shown to predict out\u2010of\u2010hospital major bleeding after myocardial infarction treated with percutaneous coronary intervention and dual antiplatelet therapy (DAPT). However, large validation studies have been scarce and the discriminative ability for patients with a preexisting bleeding risk factor (elderly, underweight, women, anemia, kidney dysfunction, or cancer) in a real\u2010world setting is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Patients undergoing percutaneous coronary intervention for myocardial infarction between 2008 and 2017 were included from the SWEDEHEART (Swedish Web System for Enhancement of Evidence\u2010Based Care in Heart Disease Evaluated According to Recommended Therapies) registry (n=66\u00a0295). The predictive value of the PRECISE\u2010DAPT score for rehospitalization with major bleeding during dual antiplatelet therapy was evaluated using receiver operating characteristic analyses. A high PRECISE\u2010DAPT score (\u226525; n=13\u00a0894) was associated with increased risk of major bleeding (3.9% versus 1.8%; hazard ratio [HR], 2.2; 95% CI, 2.0\u20132.5;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) compared with a non\u2010high score (&lt;25; n=52\u00a0401). The score demonstrated a c\u2010statistic of 0.64 (95% CI, 0.63\u20130.66). The discriminative ability of the score to further stratify bleeding risk in patients with preexisting bleeding risk factors was poor, especially in patients who are elderly (c\u2010statistic=0.57; 95% CI, 0.55\u20130.60) or underweight (c\u2010statistic=0.56; 95% CI, 0.51\u20130.61), for whom a non\u2010high PRECISE\u2010DAPT score was associated with similar bleeding risk as a high PRECISE\u2010DAPT score in the general myocardial infarction population.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In this nationwide population\u2010based study, the PRECISE\u2010DAPT score performed moderately in the general myocardial infarction population and poorly in patients with preexisting bleeding risk factors, where its usefulness seems limited.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.020974","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T12:40:26Z","timestamp":1633524026000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Validation of the 4\u2010Item PRECISE\u2010DAPT Score: A SWEDEHEART Study"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3634-6591","authenticated-orcid":false,"given":"Axel","family":"Wester","sequence":"first","affiliation":[{"name":"Department of Cardiology Clinical Sciences Lund UniversitySk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4242-9801","authenticated-orcid":false,"given":"Moman A.","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Department of Cardiology Clinical Sciences Lund UniversitySk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Olivecrona","sequence":"additional","affiliation":[{"name":"Department of Cardiology Clinical Sciences Lund UniversitySk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasminka","family":"Holmqvist","sequence":"additional","affiliation":[{"name":"Department of Cardiology Clinical Sciences Lund UniversitySk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8960-2125","authenticated-orcid":false,"given":"Troels","family":"Yndigegn","sequence":"additional","affiliation":[{"name":"Department of Cardiology Clinical Sciences Lund UniversitySk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha","family":"Koul","sequence":"additional","affiliation":[{"name":"Department of Cardiology Clinical Sciences Lund UniversitySk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706482"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904327"},{"key":"e_1_3_1_4_2","first-page":"804","article-title":"Trade\u2010off of myocardial infarction vs. bleeding types on mortality after acute coronary syndrome: lessons from the thrombin receptor antagonist for clinical event reduction in acute coronary syndrome (TRACER) randomized trial","volume":"38","author":"Valgimigli M","year":"2017","unstructured":"Valgimigli M, Costa F, Lokhnygina Y, Clare RM, Wallentin L, Moliterno DJ, Armstrong PW, White HD, Held C, Aylward PE, et al. 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