{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:04Z","timestamp":1787018104323,"version":"build-2736575974"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,11,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Blood pressure (BP) targets in elderly patients with diabetes remain unclear. We evaluated the association between BP and cardiovascular disease in elderly patients with diabetes without cardiovascular disease or heart failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We performed a retrospective cohort study of 225\u00a0563 elderly (aged \u226565\u00a0years) patients with diabetes without cardiovascular disease or heart failure from 2009 to 2017 using the National Health Information Database. We divided the participants by systolic BP (SBP) and diastolic BP. Primary composite outcomes were stroke, myocardial infarction, heart failure, and all\u2010cause death analyzed by Cox proportional hazards regression analysis adjusted for baseline covariates. During a median follow\u2010up of 7.76\u00a0years, the incidence rate of primary composite outcomes was 26.62 per 1000 person\u2010years. In multivariable Cox proportional hazard modeling, the risk of the primary outcome had a U\u2010curved association with SBP\/diastolic blood pressure with a nadir between 120 and 129\u00a0mm\u00a0Hg\/65 and 69\u00a0mm\u00a0Hg, respectively. Hypertension medication was associated with lower risk of primary composite outcomes in SBP \u2265140\u00a0mm\u00a0Hg (\n                      <jats:italic>P<\/jats:italic>\n                      for interaction for SBP &lt;0.001) and diastolic blood pressure \u226590\u00a0mm\u00a0Hg (\n                      <jats:italic>P<\/jats:italic>\n                      for interaction for diastolic blood pressure=0.018). In participants aged \u226580\u00a0years, SBP \u2265160\u00a0mm\u00a0Hg was only a marginally higher risk for primary composite outcomes (hazard ratio=1.11; 95% CI, 0.98\u20131.24).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this large sample of older Korean patients with diabetes, cardiovascular events were more common in people with resting SBP or diastolic BP \u2265140 or 95\u00a0mm\u00a0Hg, respectively, and also more common in people with resting SBP or diastolic BP &lt;120 or 65\u00a0mm\u00a0Hg, respectively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.121.020999","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T05:04:04Z","timestamp":1635829444000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Blood Pressure and Cardiovascular Disease in Older Patients With Diabetes: Retrospective Cohort Study"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8535-0565","authenticated-orcid":false,"given":"Sangmo","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hanyang UniversityCollege of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3941-4836","authenticated-orcid":false,"given":"Jung Hwan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hanyang UniversityCollege of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9622-0643","authenticated-orcid":false,"given":"Kyungdo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Statistics and Actuarial Science Soongsil University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4891-834X","authenticated-orcid":false,"given":"Chang Beom","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hanyang UniversityCollege of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1256-7648","authenticated-orcid":false,"given":"Dong Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hanyang UniversityCollege of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4391-4526","authenticated-orcid":false,"given":"Sung Hoon","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hanyang UniversityCollege of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2019.0067"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2018.0017"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115517"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7258.412"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2015.39.5.395"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7160.703"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001286"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61303-8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.016337"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001323"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11911-8"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy339"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15026"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000065"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-S010"},{"key":"e_1_3_2_17_2","first-page":"e15","article-title":"Cohort profile: the national health insurance service\u2010national sample cohort (NHIS\u2010NSC), South Korea","volume":"46","author":"Lee J","year":"2017","unstructured":"Lee J, Lee JS, Park SH, Shin SA, Kim K. Cohort profile: the national health insurance service\u2010national sample cohort (NHIS\u2010NSC), South Korea. 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