{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:05:16Z","timestamp":1793059516430,"version":"4.5.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,8,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">There is a lack of contemporary data on cardiogenic shock (CS) in\u2010hospital mortality trends.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Patients with CS admitted January 1, 2004 to December 31, 2018, were identified from the US National Inpatient Sample. We reported the crude and adjusted trends of in\u2010hospital mortality among the overall population and selected subgroups. Among a total of 563\u00a0949\u00a0644 hospitalizations during the period from January 1, 2004, to December 30, 2018, 1\u00a0254\u00a0358 (0.2%) were attributed to CS. There has been a steady increase in hospitalizations attributed to CS from 122 per 100\u00a0000 hospitalizations in 2004 to 408 per 100\u00a0000 hospitalizations in 2018 (\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>trend<\/jats:sub>\n              &lt;0.001). This was associated with a steady decline in the adjusted trends of in\u2010hospital mortality during the study period in the overall population (from 49% in 2004 to 37% in 2018;\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>trend<\/jats:sub>\n              &lt;0.001), among patients with acute myocardial infarction CS (from 43% in 2004 to 34% in 2018;\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>trend<\/jats:sub>\n              &lt;0.001), and among patients with non\u2013acute myocardial infarction CS (from 52% in 2004 to 37% in 2018;\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>trend<\/jats:sub>\n              &lt;0.001). Consistent trends of reduced mortality were seen among women, men, different racial\/ethnic groups, different US regions, and different hospital sizes, regardless of the hospital teaching status.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Hospitalizations attributed to CS have tripled in the period from January 2004 to December 2018. However, there has been a slow decline in CS in\u2010hospital mortality during the studied period. Further studies are necessary to determine if the recent adoption of treatment algorithms in treating patients with CS will further impact in\u2010hospital mortality.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.021061","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T08:55:40Z","timestamp":1627462540000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":197,"title":["Fifteen\u2010Year Trends in Incidence of Cardiogenic Shock Hospitalization and In\u2010Hospital Mortality in the United States"],"prefix":"10.1161","volume":"10","author":[{"given":"Mohammed","family":"Osman","sequence":"first","affiliation":[{"name":"Division of Cardiology West Virginia University School of Medicine Morgantown WV"},{"name":"Knight Cardiovascular Institute Oregon Health and Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moinuddin","family":"Syed","sequence":"additional","affiliation":[{"name":"Division of Cardiology West Virginia University School of Medicine Morgantown WV"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saikrishna","family":"Patibandla","sequence":"additional","affiliation":[{"name":"Division of Cardiology West Virginia University School of Medicine Morgantown WV"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samian","family":"Sulaiman","sequence":"additional","affiliation":[{"name":"Division of Cardiology West Virginia University School of Medicine Morgantown WV"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babikir","family":"Kheiri","sequence":"additional","affiliation":[{"name":"Knight Cardiovascular Institute Oregon Health and Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5065-3355","authenticated-orcid":false,"given":"Mahek K.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Cardiology Thomas Jefferson University Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Bianco","sequence":"additional","affiliation":[{"name":"Division of Cardiology West Virginia University School of Medicine Morgantown WV"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7872-3757","authenticated-orcid":false,"given":"Sudarshan","family":"Balla","sequence":"additional","affiliation":[{"name":"Division of Cardiology West Virginia University School of Medicine Morgantown WV"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8973-8228","authenticated-orcid":false,"given":"Brijesh","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Cardiology West Virginia University School of Medicine Morgantown WV"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.96"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28307"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2020.08.012"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.12.084"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11936-020-0804-6"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.040654"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.10.040"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-017-1182-2"},{"key":"e_1_3_1_10_2","unstructured":"HCUP National Readmission Database (NRD) . Healthcare Cost and Utilization Project (HCUP). Agency Healthcare Research Quality R M. Available at: https:\/\/www.hcup\u2010us.ahrq.gov\/nrdoverview.jsp. Accessed May 2 2021."},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2020.05.004"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29222"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29282"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2020.06.064"},{"key":"e_1_3_1_15_2","article-title":"Index admission and thirty\u2010day readmission outcomes of patients with cancer presenting with STEMI","volume":"21","author":"Osman M","year":"2021","unstructured":"Osman M, Benjamin MM, Balla S, Kheiri B, Bianco C, Sengupta PP, Daggubati R, Malla M, Liu SV, Mamas M, et al. Index admission and thirty\u2010day readmission outcomes of patients with cancer presenting with STEMI. Cardiovasc Revasc Med. 2021;21:S1553\u20108389(21)00203\u20107. DOI: 10.1016\/j.carrev.2021.04.015.","journal-title":"Cardiovasc Revasc Med"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2021.03.033"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-015-0013-2"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2011.10.005"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2008.02.065"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2021.02.028"},{"key":"e_1_3_1_21_2","unstructured":"Available at: http:\/\/www.abiomed.com\/products\/impella\u20102\u20105\/ IAAo. Accessed February 22 2021."},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2020.09.005"},{"key":"e_1_3_1_23_2","first-page":"52","article-title":"Experts\u2019 recommendations for the management of adult patients with cardiogenic shock","volume":"5","author":"Levy B","year":"2015","unstructured":"Levy B, Bastien O, Bendjelid K, Cariou A, Chouihed T, Combes A, Mebazaa A, Megarbane B, Plaisance P, Ouattara A, et al. Experts\u2019 recommendations for the management of adult patients with cardiogenic shock. Ann Intensive Care. 2015;5:52. DOI: 10.1186\/s13613\u2010015\u20100052\u20101.","journal-title":"Ann Intensive Care"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu029"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199801000-00004"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2019.05.012"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2020.10.054"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.118.007293"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2019.03.004"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000590"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908263410901"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.12.004"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2014-000109"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1127"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.117.004010"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.043080"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000525"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.10.039"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4536-8"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(19)30108-2"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.121.021061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:49:12Z","timestamp":1715600952000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.121.021061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,3]]},"references-count":39,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2021,8,3]]}},"alternative-id":["10.1161\/JAHA.121.021061"],"URL":"https:\/\/doi.org\/10.1161\/jaha.121.021061","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,3]]},"assertion":[{"value":"2021-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e021061"}}