{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:53:37Z","timestamp":1790016817414,"version":"4.0.1"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,7,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Factors related to health\u2010related quality of life (HRQOL) 2\u00a0years after left ventricular assist device (LVAD) implantation are unknown. We sought to determine whether preimplant intended goal of LVAD therapy (heart transplant candidate [short\u2010term group], uncertain heart transplant candidate [uncertain group], and heart transplant ineligible [long\u2010term group]) and other variables were related to HRQOL 2\u00a0years after LVAD implantation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Our LVAD sample (n=1620) was from INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support). Using the EuroQol\u20105 Dimension Questionnaire (EQ\u20105D\u20103L), a generic HRQOL measure, and the Kansas City Cardiomyopathy Questionnaire (KCCQ\u201012), a heart failure\u2013specific HRQOL measure, multivariable linear regression modeling was conducted with the EQ\u20105D\u20103L Visual Analog Scale (VAS) score and KCCQ\u201012 overall summary score (OSS) as separate dependent variables. Two years after LVAD implant, the short\u2010term group had a significantly higher mean VAS score versus the uncertain and long\u2010term groups (short\u2010term: 75.18 [SD, 20.62]; uncertain: 72.27 [SD, 20.33]; long\u2010term: 70.87 [SD, 22.09],\n              <jats:italic>P<\/jats:italic>\n              =0.01); differences were not clinically meaningful. Two\u2010year mean scores did not differ by group for the KCCQ\u201012 OSS (short\u2010term, 67.85 [SD, 20.61]; uncertain, 67.79 [SD, 19.31]; long\u2010term, 67.08 [SD, 21.49],\n              <jats:italic>P<\/jats:italic>\n              =0.80). Factors associated with a worse VAS score 2\u00a0years postoperatively (n=1205) included not working; not having a short\u2010term LVAD; and postoperative neurological dysfunction, greater health\u2010related stress, coping poorly, less VAD self\u2010care confidence, and less satisfaction with VAD surgery, explaining 28% of variance (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Factors associated with a worse KCCQ\u201012 OSS 2\u00a0years postoperatively (n=1250) included not working; history of high body mass index and diabetes mellitus; and postoperative renal dysfunction, greater health\u2010related stress, coping poorly, less VAD self\u2010care confidence, less satisfaction with VAD surgery, and regret regarding VAD implantation, accounting for 36% of variance (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Factors related to HRQOL 2\u00a0years after LVAD implantation include demographic, clinical, and psychological variables.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.021196","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T08:55:29Z","timestamp":1625820929000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Factors Associated With Health\u2010Related Quality of Life 2 Years After Left Ventricular Assist Device Implantation: Insights From INTERMACS"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6570-5365","authenticated-orcid":false,"given":"Kathleen L.","family":"Grady","sequence":"first","affiliation":[{"name":"Department of Surgery Northwestern University Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pariya L.","family":"Fazeli","sequence":"additional","affiliation":[{"name":"Department of Family, Community, and Health Systems University of Alabama at Birmingham School of Nursing Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James K.","family":"Kirklin","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Alabama at Birmingham Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salpy V.","family":"Pamboukian","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Alabama at Birmingham Birmingham AL"},{"name":"Department of Medicine University of Alabama at Birmingham Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"White\u2010Williams","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Hospital Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.01.1222"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.10.019"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.10.017"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.10.001"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.10.002"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.116.003910"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.11.013"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2016.01.006"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.12.052"},{"key":"e_1_3_1_11_2","unstructured":"https:\/\/www.sts.org\/registries\u2010research\u2010center\/sts\u2010national\u2010database\/intermacs\u2010database."},{"key":"e_1_3_1_12_2","volume-title":"Quality of Life and Pharmacoeconomics in Clinical Trials","author":"Spilker B","year":"1996","unstructured":"Spilker B. 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