{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:44:47Z","timestamp":1771303487117,"version":"3.50.1"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,11,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">There are limited data on the lifetime risk of heart failure (HF) in people with type 2 diabetes and how incidence has changed over time. We estimated the cumulative incidence and incidence rates of HF among Danish adults with type 2 diabetes between 1995 and 2018 using nationwide data.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In total, 398\u00a0422 patients (49% women) with type 2 diabetes were identified. During follow\u2010up, 36\u00a0400 (9%) were diagnosed with HF and 121\u00a0459 (30%) were censored due to death. Using the Aalen\u2010Johansen estimators, accounting for the risk of death, the estimated residual lifetime risk of HF at age 50\u00a0years was calculated as 24% (95% CI 22%\u201327%) in women and 27% (25%\u201328%) in men. During the observational period, the proportion of patients treated with statins, angiotensin\u2010converting enzyme inhibitors or angiotensin II receptor blockers, and metformin increased from &lt;30% to &gt;60%. Similarly, the annual incidence rates of HF decreased significantly, with declines being greater in older versus younger individuals (5% versus 2% in age &gt;50 versus \u226450\u00a0years, respectively;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) and in women versus men (5% versus 4%,\n              <jats:italic>P<\/jats:italic>\n              =0.02), but similar in patients with and without IHD (4% versus 4%,\n              <jats:italic>P<\/jats:italic>\n              =0.53).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The current lifetime risk of HF in type 2 diabetes approximates 1 in 4 for men and women. Paralleled by an increase in use of evidence\u2010based pharmacotherapy over the past decades, the risk of developing HF has declined across several subgroups and regardless of underlying IHD, suggesting that optimal diabetes treatment can mitigate HF risk.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.021230","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T09:03:21Z","timestamp":1635498201000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Lifetime Risk of Heart Failure and Trends in Incidence Rates Among Individuals With Type 2 Diabetes Between 1995 and 2018"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5087-9293","authenticated-orcid":false,"given":"Brian","family":"Schwartz","sequence":"first","affiliation":[{"name":"Department of Medicine Section of Internal Medicine Boston Medical CenterBoston University School of 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