{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T06:13:31Z","timestamp":1786515211192,"version":"build-2736575974"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,7,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>BACKGROUND<\/jats:title>\n            <jats:p xml:lang=\"en\">In this scoping review, we identified and reviewed 23 original articles from the PubMed database that investigated the relationship between nonacute opioid use (NOU) and cardiovascular outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>METHODS AND RESULTS<\/jats:title>\n            <jats:p xml:lang=\"en\">We defined NOU to include both long\u2010term opioid therapy and opioid use disorder. We summarized the association between NOU and 5 classes of cardiovascular disease, including infective endocarditis, coronary heart disease (including myocardial infarction), congestive heart failure, cardiac arrythmia (including cardiac arrest), and stroke. The most commonly studied outcomes were coronary heart disease and infective endocarditis. There was generally consistent evidence of a positive association between community prevalence of injection drug use (with opioids being the most commonly injected type of drug) and community prevalence of infective endocarditis, and between (primarily medically indicated) NOU and myocardial infarction. There was less consensus about the relationship between NOU and congestive heart failure, cardiac arrhythmia, and stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>CONCLUSIONS<\/jats:title>\n            <jats:p xml:lang=\"en\">There is a dearth of high\u2010quality evidence on the relationship between NOU and cardiovascular disease. Innovative approaches to the assessment of opioid exposure over extended periods of time will be required to address this need.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.021260","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T13:07:19Z","timestamp":1625317639000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Association of Nonacute Opioid Use and Cardiovascular Diseases: A Scoping Review of the Literature"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7736-8570","authenticated-orcid":false,"given":"Jade H.","family":"Singleton","sequence":"first","affiliation":[{"name":"Department of Epidemiology College of Public Health University of Kentucky Lexington KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9566-4111","authenticated-orcid":false,"given":"Erin L.","family":"Abner","sequence":"additional","affiliation":[{"name":"Department of Epidemiology College of Public Health University of Kentucky Lexington KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6968-686X","authenticated-orcid":false,"given":"Peter D.","family":"Akpunonu","sequence":"additional","affiliation":[{"name":"Emergency Medicine &amp; Medical Toxicology University of Kentucky Hospital Lexington KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9864-467X","authenticated-orcid":false,"given":"Anna M.","family":"Kucharska\u2010Newton","sequence":"additional","affiliation":[{"name":"Department of Epidemiology College of Public Health University of Kentucky Lexington KY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198001103020221"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6731a1"},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0229174","article-title":"National U.S. time\u2010trends in opioid use disorder hospitalizations and associated healthcare utilization and mortality","volume":"15","author":"Singh JA","year":"2020","unstructured":"Singh JA, Cleveland JD. 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