{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T22:08:16Z","timestamp":1770329296909,"version":"3.49.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,7,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Contrast\u2010induced acute kidney injury (CI\u2010AKI) is a serious complication after percutaneous coronary intervention. The mainstay of CI\u2010AKI prevention is represented by intravenous hydration. Tailoring infusion rate to patient volume status has emerged as advantageous over fixed infusion\u2010rate hydration strategies.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A systematic review and network meta\u2010analysis with a frequentist approach were conducted. A total of 8 randomized controlled trials comprising 2312 patients comparing fixed versus tailored hydration strategies to prevent CI\u2010AKI after percutaneous coronary intervention were included in the final analysis. Tailored hydration strategies included urine flow rate\u2013guided, central venous pressure\u2013guided, left ventricular end\u2010diastolic pressure\u2013guided, and bioimpedance vector analysis\u2013guided hydration. Primary endpoint was CI\u2010AKI incidence. Safety endpoint was incidence of pulmonary edema. Urine flow rate\u2013guided and central venous pressure\u2013guided hydration were associated with a lower incidence of CI\u2010AKI compared with fixed\u2010rate hydration (odds ratio [OR], 0.32 [95% CI, 0.19\u20130.54] and OR, 0.45 [95% CI, 0.21\u20130.97]). No significant difference in pulmonary edema incidence was observed between the different hydration strategies.\n              <jats:italic>P<\/jats:italic>\n              score analysis showed that urine flow rate\u2013guided hydration is advantageous in terms of both CI\u2010AKI prevention and pulmonary edema incidence when compared with other approaches.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Currently available hydration strategies tailored on patients' volume status appear to offer an advantage over guideline\u2010supported fixed\u2010rate hydration for CI\u2010AKI prevention after percutaneous coronary intervention. Current evidence suggests that urine flow rate\u2013guided hydration as the most convenient strategy in terms of effectiveness and safety.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.021342","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T09:09:17Z","timestamp":1624612157000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Tailored Versus Standard Hydration to Prevent Acute Kidney Injury After Percutaneous Coronary Intervention: Network Meta\u2010Analysis"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6101-1403","authenticated-orcid":false,"given":"Francesco","family":"Moroni","sequence":"first","affiliation":[{"name":"Division of Cardiology Virginia Commonwealth University Health Pauley Heart CenterVirginia Commonwealth University Richmond VA"},{"name":"Universit\u00e0 Vita\u2010Salute San Raffaele Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5986-049X","authenticated-orcid":false,"given":"Luca","family":"Baldetti","sequence":"additional","affiliation":[{"name":"Coronary Intensive Care Unit IRCCS Ospedale San Raffaele Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0553-0305","authenticated-orcid":false,"given":"Conrad","family":"Kabali","sequence":"additional","affiliation":[{"name":"Division of Epidemiology Dalla Lana School of Public Health University of Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2105-8186","authenticated-orcid":false,"given":"Carlo","family":"Briguori","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit Mediterranea Cardiocentro Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Maioli","sequence":"additional","affiliation":[{"name":"Division of Cardiology Santo Stefano Hospital Prato Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8404-3993","authenticated-orcid":false,"given":"Anna","family":"Toso","sequence":"additional","affiliation":[{"name":"Division of Cardiology Santo Stefano Hospital Prato Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9416-9701","authenticated-orcid":false,"given":"Emmanouil S.","family":"Brilakis","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute and Minneapolis Heart Institute Foundation Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitinder S.","family":"Gurm","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine University of Michigan Ann Arbor MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Bagur","sequence":"additional","affiliation":[{"name":"London Health Science Centre Western University London Ontario Canada"},{"name":"Department of Epidemiology and Biostatistics Schulich School of Medicine &amp; 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