{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T15:30:16Z","timestamp":1788017416271,"version":"build-2784847793"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"23","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,12,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Left atrial (LA) and right ventricular (RV) performance play an integral role in the pathophysiology and prognosis of heart failure. We hypothesized that subclinical left ventricular dysfunction adversely affects LA\/RV geometry and function even in a preclinical setting. This study aimed to investigate the atrioventricular and ventricular functional interdependence in a community\u2010based cohort without overt cardiovascular disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Left ventricular global longitudinal strain (LVGLS), RV free\u2010wall longitudinal strain and LA phasic strain were assessed by speckle\u2010tracking echocardiography in 1080 participants (600 men; 62\u00b112\u00a0years) between 2014 and 2018. One hundred and forty\u2010three participants (13.2%) had an abnormal LVGLS (&gt;\u221218.6%). LA reservoir strain, conduit strain, and RV free\u2010wall longitudinal strain were significantly decreased in abnormal LVGLS group compared with normal LVGLS group (all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). LA and RV dysfunction (LA reservoir strain&lt;31.4% and RVLS&gt;\u221219.2%) were present in 18.9% and 19.6% of participants with abnormal LVGLS. Decreased LVGLS was associated with worse LA reservoir strain, conduit strain and RV free\u2010wall longitudinal strain (standardized \u03b2=\u22120.20, \u22120.19 and 0.11 respectively, all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01) independent of cardiovascular risk factors. LA and\/or RV dysfunction concomitant with abnormal LVGLS carried significantly increased risk of elevated B\u2010type natriuretic peptide levels (&gt;28.6\u00a0pg\/mL for men and &gt;44.4\u00a0pg\/mL for women) compared with normal LVGLS (odds ratio, 2.01;\n              <jats:italic>P<\/jats:italic>\n              =0.030).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">LA\/RV dysfunction was present in 20% individuals with abnormal LVGLS and multi\u2010chamber impairment was associated with elevated B\u2010type natriuretic peptide level, which may provide valuable insights for a better understanding of atrioventricular and ventricular interdependence and possibly heart failure preventive strategies.<\/jats:p>\n          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